| Guillermo González | |
| Office: | Governor of Cauca |
| Predecessor: | Juan José Chaux |
| Successor: | Temitocles Ortega |
| Office1: | Minister of National Defense |
| President1: | Ernesto Samper |
| Predecessor1: | Juan Carlos Esguerra |
| Successor1: | Gilberto Echeverri Mejía |
| Office2: | Senator of Colombia |
| Office3: | Member of the Chamber of Representatives |
| Constituency3: | Cauca |
| Office4: | Minister Labour and Social Security |
| Term Start4: | 1983 |
| Term End4: | 1984 |
| President4: | Belisario Betancur |
| Predecessor4: | Jaime Pinzón López |
| Successor4: | Germán Bula Escobar |
| Birth Name: | Gilberto Alberto González Mosquera |
| Birth Date: | 12 February 1941 |
| Birth Place: | Popayán, Cauca, Colombia |
| Death Place: | Popayán, Cauca, Colombia |
| Spouse: | María Teresa Ayerbe |
| Party: | Liberal |
| Children: | 4 |
| Alma Mater: | University of Cauca Purdue University |
| Profession: | Civil engineer, diplomat, politician |
Guillermo Alberto González Mosquera (12 February 1941 – 5 August 2021) was a Colombian politician who served as a Minister, Governor of Cauca, Senator and Mayor of Popayán.[1]