| Guido De Santi | |
| Fullname: | Guido De Santi |
| Birth Date: | 1923 5, df=yes |
| Birth Place: | Trieste, Italy |
| Death Place: | Trieste, Italy |
| Discipline: | Road |
| Role: | Rider |
| Proyears1: | 1946–1948 |
| Proteam1: | Wilier Triestina |
| Proyears2: | 1949–1950 |
| Proteam2: | Atala |
| Proyears3: | 1950–1953 |
| Proteam3: | Colomb-Manera |
| Proyears4: | 1951 |
| Proteam4: | Patria W.K.C. |
| Proyears5: | 1951–1953 |
| Proteam5: | Benotto-Ursus-Fiorelli |
| Proyears6: | 1952 |
| Proteam6: | Rapier |
| Proyears7: | 1954 |
| Proteam7: | Bottecchia |
| Proyears8: | 1955 |
| Proteam8: | Leo-Chlorodont |
| Proyears9: | 1956–1957 |
| Proteam9: | Ignis-Varese |
Guido De Santi (16 May 1923 – 30 October 1998) was an Italian racing cyclist. He won the 1951 Deutschland Tour. He also rode in the 1948 and 1949 Tour de France.[1] [2]