| Guaxindiba River | |
| Pushpin Map: | Brazil |
| Source1 Location: | Rio de Janeiro state |
| Mouth Location: | Guanabara Bay |
| Mouth Coordinates: | -22.7432°N -43.0265°W |
| Mouth Elevation: | 0m (00feet) |
| Subdivision Type1: | Country |
| Subdivision Name1: | Brazil |
The Guaxindiba River (pt|Rio Guaxindiba) is a river of Rio de Janeiro state in southeastern Brazil.
The Guaxindiba River flows through a flat region of mangroves in the Guanabara Ecological Station before discharging into the east of Guanabara Bay near the city of Rio de Janeiro.