Growing teeth explained

Growing teeth is a bioengineering technology with the ultimate goal to create new full molars in a person or an animal.

Chronology

• 2002 – British scientists have learned how to grow almost whole, but feeble teeth from single cells.
• 2007 – Japanese scientists have bred mice almost full new teeth, but without a root.
• 2009 – from the stem cells were grown full teeth in mice, and even managed to grow a tooth root, previously it was not possible, but there is a problem, it is that grown teeth were slightly less "native" teeth.^[1]
• 2013 - Chinese scientists grow human teeth in mice using stem cells taken from human urine.^[2]
• 2015 - Growing New Teeth in the Mouth Using Stem-Cell Dental Implants ^[3]
• 2018 - Protein disorder–order interplay to guide the growth of hierarchical mineralized structures.^[4]

Methods

• Outer – the tooth is grown separately and implanted in the patient.
• Inner – the tooth is grown directly into the patient's mouth.

Regenerative Research

• 2012 – Indian researchers found a way to cure and regenerate an infected root canal through stem cell activation. This replaces the old method of removing the tooth nerve.^[5]
• 2013 - Swiss researchers regenerate tooth enamel of early cavities using a peptide-based biomaterial.^[6]

Links

• Alligators Inspire New Way for Growing Teeth

Notes and References

1. News: Normile . Dennis . Researchers Grow New Teeth in Mice . Science . 3 August 2009 .
2. Web site: Stem cells extracted from urine used to 'grow teeth' - NHS . 23 March 2014 . 9 March 2017 . https://web.archive.org/web/20170309111202/http://www.nhs.uk/news/2013/07July/Pages/Stem-cells-extracted-from-urine-used-to-grow-teeth.aspx/ . dead .
3. Web site: Growing New Teeth in the Mouth Using Stem-Cell Dental Implants . PreScouter . 26 July 2015.
4. Elsharkawy . Sherif . Al-Jawad . Maisoon . Pantano . Maria F. . Tejeda-Montes . Esther . Mehta . Khushbu . Jamal . Hasan . Agarwal . Shweta . Shuturminska . Kseniya . Rice . Alistair . Tarakina . Nadezda V. . Wilson . Rory M. . Bushby . Andy J. . Alonso . Matilde . Rodriguez-Cabello . Jose C. . Barbieri . Ettore . del Río Hernández . Armando . Stevens . Molly M. . Pugno . Nicola M. . Anderson . Paul . Mata . Alvaro . Protein disorder–order interplay to guide the growth of hierarchical mineralized structures . Nature Communications . 1 June 2018 . 9 . 1 . 2145 . 10.1038/s41467-018-04319-0 . 29858566 . 5984621 . 2018NatCo...9.2145E .
5. News: Breakthrough dentistry. The Hindu. September 2013. Dutt. Anuradha.
6. Brunton . P. A. . Davies . R. P. W. . Burke . J. L. . Smith . A. . Aggeli . A. . Brookes . S. J. . Kirkham . J. . Treatment of early caries lesions using biomimetic self-assembling peptides – a clinical safety trial . British Dental Journal . August 2013 . 215 . 4 . E6 . 10.1038/sj.bdj.2013.741 . 23969679 . 3813405 .