| Groote Schuur High School | |
| Location: | Newlands |
| Streetaddress: | 77 Palmyra Rd |
| Region: | Southern Suburbs |
| City: | Cape Town |
| Province: | Western Cape |
| Postalcode: | 7700 |
| Country: | South Africa |
| Head Label: | Headmaster |
| Head: | Marius Ehrenreich |
| Schooltype: | Co-educational public school |
| Grades: | 812 |
| Gender: | co-educational |
| Language: | English |
| Website: | https://www.gshs.co.za/ |
Groote Schuur High School (formerly Hoërskool Groote Schuur) is a public English medium high school situated in Newlands – part of the Southern Suburbs region of Cape Town in the Western Cape province of South Africa. Founded in 1959 as an Afrikaans medium school in 1959, it was reserved for white pupils during the apartheid era. It became multiracial in the 1990s, when it became parallel-medium, with classes offered in both English and Afrikaans. English became the sole medium of instruction in 2011.