| Große Pyra | |
| Mouth Coordinates: | 50.4586°N 12.4897°W |
| Subdivision Type1: | Country |
| Subdivision Name1: | Germany |
| Subdivision Type2: | States |
| Subdivision Name2: | Saxony |
The Große Pyra is a river of Saxony, Germany. It is a right tributary of the Zwickauer Mulde, which it joins in Morgenröthe-Rautenkranz.