| Type: | Ortsteil |
| Municipality: | Hohe Börde |
| Image Coa: | DE-ST 15-0-83-298 Gross Santersleben COA.png |
| Coordinates: | 52.1833°N 38°W |
| State: | Sachsen-Anhalt |
| District: | Börde |
| Elevation: | 133 |
| Area: | 7.09 |
| Population: | 1050 |
| Stand: | 2006-12-31 |
| Postal Code: | 39343 |
| Area Code: | 039206 |
| Website: | www.gross-santersleben.de |
Groß Santersleben is a village and a former municipality in the Börde district in Saxony-Anhalt, Germany. Since 1 January 2010, it has been part of the Hohe Börde municipality.