| Greenville High School | |
| Streetaddress: | 4976 State Route 81 |
| City: | Greenville |
| State: | New York |
| County: | (Greene County) |
| Zipcode: | 12083 |
| Country: | USA |
| Coordinates: | 42.4183°N -74.027°W |
| Schooltype: | high school |
| Fundingtype: | Public school (government funded) |
| District: | Greenville Central School District |
| Superintendent: | Tammy Sutherland |
| Ceeb: | 332190 |
| Principal: | Matthew Ward |
| Faculty: | 39.59 (FTE) |
| Grades: | 9 - 12; Ungraded |
| Gender: | Coeducational |
| Enrollment: | 359 (2022-23)[1] |
| Other Grade Label 1: | Ungraded |
| Ratio: | 9.07 |
| Language: | English |
| Campus: | Rural: Distant |
| Colors: | Maroon and White |
| Mascot: | Spartans |
Greenville High School is a public high school located in Greenville, Greene County, New York, U.S.A., and is the only high school operated by the Greenville Central School District.