Ceramide glucosyltransferase explained

Ceramide glucosyltransferase (or glucosylceramide synthase) is a glucosyltransferase enzyme involved in the production of glucocerebrosides (also called glucosylceramides). It is responsible for the first step in synthesis of all glycosphingolipids—critical components of cell membranes—from sphingolipids, attaching a glucose molecule (glycosylation) to produce a glucocerebroside product.^[1] The enzyme is classified under .

Notes and References

1. Ichikawa S, Sakiyama H, Suzuki G, Hidari KI, Hirabayashi Y . Expression cloning of a cDNA for human ceramide glucosyltransferase that catalyzes the first glycosylation step of glycosphingolipid synthesis . Proceedings of the National Academy of Sciences of the United States of America . 93 . 10 . 4638–43 . May 1996 . 8643456 . 39331 . 10.1073/pnas.93.10.4638 . free .