Georgina Xanthou Explained

Georgina Xanthou
Awards:Romain Pauwels Research Excellence Award, European Respiratory Society (2009)
UNESCO Award for Women in Science (2009)
Education:BSc in Biomedical Sciences
PhD in Immunology
Alma Mater:National and Kapodistrian University of Athens
Imperial College London
Workplaces:Biomedical Research Foundation of the Academy of Athens

Georgina Xanthou is an immunologist who serves as an associate professor at the Biomedical Research Foundation of the Academy of Athens.[1]

Xanthou's research focuses on autoimmune and allergic diseases, particularly in understanding of immunological mechanisms through which cytokines control T cell pathogenicity towards environmental allergens and self-antigens. She has received awards, including the Romain Pauwels Research Excellence Award by the European Respiratory Society,[2] the Allergopharma Award by the European Academy of Allergy and Clinical Immunology,[3] and the UNESCO L’Oreal Award for Women in Science.[4]

Xanthou serves as a board member on scientific advisory and grant review boards, as well as a peer scientific reviewer for journals, including PNAS, Nature, AJRCCM, European Respiratory Journal.[5]

Education and career

Xanthou holds a BSc in Biomedical Sciences from the Department of Biology in the National and Kapodistrian University of Athens, and a PhD in Immunology from the University of Athens, Medical School. She completed a European Molecular Biology Organization-funded postdoctoral fellowship in the Division of Biomedical Sciences at the Faculty of Medicine in Imperial College, London.[6]

In 2003, Xanthou was appointed as an instructor in the Cellular Immunology Laboratory at Biomedical Research Foundation Academy of Athens (BRFAA). She became an Assistant Professor in 2007 and has been an Associate Professor and Group Leader since 2019.[7] In 2021-2023, she served as a Visiting Professor/Senior Project Scientist at University of California, Los Angeles.[8]

Research

Xanthou has published over 50 peer-reviewed articles and book chapters. Her publications have been published in scientific journals, including Cell, Nature Reviews Immunology, Nature Immunology, JEM, JACI, Science-Business eXchange, Faculty of Medicine 1000, Global Medical Discovery Series, PNAS USA. [9]

Xanthou's research focuses on immunology and inflammation, and more specifically on the role of dendritic cells and T cells in the regulation of autoimmune and allergic diseases,[10] [11] [12] [13] as well as cancer. In one of her highly cited articles, she demonstrated that the cytokine, osteopontin has a dual role in allergic airway disease, being pro-inflammatory during initial allergen sensitization and anti-inflammatory during subsequent allergen challenges, and highlighted its potential as a therapeutic target for allergic diseases.[10] Her group has also made contributions to studying the role of the cytokine activin-A in regulating T Cell immune responses in the context of allergy, autoimmunity, and cancer.[14] [15] [16] [17]

Awards and honors

Selected articles

Notes and References

  1. Web site: Scientific Personnel - Profile . Biomedical Research Foundation . Academy of Athens.
  2. Romain Pauwels Award (supported by GlaxoSmithKline) . registration . ERS . The ERS International Congress 2009, Vienna.
  3. Web site: Allergopharma Award, EAACI Executive Committee . Allergopharma.
  4. Web site: Georgina Xanthou, PhD . The Michael J. Fox Foundation.
  5. Web site: List of European Respiratory Journal peer reviewers 2020.
  6. Web site: Xanthou Georgina- Bio . Information Technologies in Medicine and Biology.
  7. Web site: Xanthou Lab . Biomedical Research Foundation . Academy of Athens.
  8. Web site: Jacobs LabFormer Lab Members . UCLA Health.
  9. Web site: Georgina Xanthou - Google Scholar Profile.
  10. Xanthou . Georgina . Alissafi . Themis . Semitekolou . Maria . Simoes . Davina C M . Economidou . Erasmia . Gaga . Mina . Lambrecht . Bart N . Lloyd . Clare M . Panoutsakopoulou . Vily . 2007-04-15 . Osteopontin has a crucial role in allergic airway disease through regulation of dendritic cell subsets . . 13 . 570-578 . 10.1038/nm1580 . 11289211 . 17435770 . 3384679.
  11. Simoes . Davina C M . Xanthou . Georgina . Petrochilou . Kalomira . Panoutsakopoulou . Vily . Roussos . Charis . Gratziou . Christina . 2009-05-15 . Osteopontin Deficiency Protects against Airway Remodeling and Hyperresponsiveness in Chronic Asthma . . 179 . 10 . 894-902 . 10.1164/rccm.200807-1081OC . 45303355 . 19234104.
  12. Tousa . Sofia . Semitekolou . Maria . Christopoulou . Ioanna . Samitas . Konstantinos . Paraskevopoulos . Giannis . Hawrylowicz . Catherine . Gaga . Mina . Xanthou . Georgina . 2011-09-01 . Critical immunoregulatory role for activin-A in human allergic asthma . . 38 . Supplement 55 . 70475520 .
  13. Theofani . Efthymia . Semitekolou . Maria . Morianos . Ioannis . Samitas . Konstantinos . Xanthou . Georgina . 2019-10-04 . Targeting NLRP3 Inflammasome Activation in Severe Asthma . . 8 . 10 . 1615 . 10.3390/jcm8101615 . free . 203924809. 6833007 .
  14. Semitekolou . Maria . Alissafi . Themis . Aggelakopoulou . Maria . Kourepini . Evangelia . Kariyawasam . Harsha H. . Kay . Anthony B. . Robinson . Douglas S. . Lloyd . Clare M. . Panoutsakopoulou . Vily . Xanthou . Georgina . 2009-08-03 . Activin-A induces regulatory T cells that suppress T helper cell immune responses and protect from allergic airway disease . . 206 . 8 . 1769-1785 . 10.1084/jem.20082603 . 6442428 . 19620629 . 2722168.
  15. Kariyawasam . Harsha H . Pegorier . Sophie . Barkans . Julia . Xanthou . Georgina . Aizen . Maxine . Ying . Sun . Kay . A. Barry . Lloyd . Clare M. . Robinson . Douglas S. . September 2009 . Activin and transforming growth factor-beta signaling pathways are activated after allergen challenge in mild asthma . . 124 . 3 . 454-462 . 10.1016/j.jaci.2009.06.022 . 3725145 . 19733294 . 4579560.
  16. Sofia . Tousa . Semitekolou . Maria . Morianos . Ioannis . Banos . Aggelos . Trochoutsou . Aikaterini I. . Brodie . Tess M. . Poulos . Nikolaos . Samitas . Konstantinos . Kapasa . Maria . Konstantopoulos. Dimitris . Paraskevopoulos . Giannis . Gaga . Mina . Hawrylowicz . Catherine M. . Sallusto . Federica . Xanthou . Georgina . 2017-03-20 . Activin-A co-opts IRF4 and AhR signaling to induce human regulatory T cells that restrain asthmatic responses . . 114 . 14 . E2891-E2900 . 10.1073/pnas.1616942114 . free . 4733152 . 28320933 . 5389328.
  17. Morianos . Ioannis . Papadopoulou . Gina . Semitekolou . Maria . Xanthou . Georgina . November 2019 . Activin-A in the regulation of immunity in health and disease . . 10.1016/j.jaut.2019.102314 . free . 201019116 . 31416681.

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