GRIK5 explained
Glutamate receptor, ionotropic kainate 5 is a protein that in humans is encoded by the GRIK5 gene.[1] [2]
Function
This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members.
Interactions
GRIK5 has been shown to interact with DLG4[3] [4] and GRIK2.[5] [6]
See also
Further reading
- Kamboj RK, Schoepp DD, Nutt S, etal . Molecular structure and pharmacological characterization of humEAA2, a novel human kainate receptor subunit. . Mol. Pharmacol. . 42 . 1 . 10–5 . 1992 . 1321949 .
- Cauley K, Kukekov V, Young D . Kainate/AMPA receptors expressed on human fetal astrocytes in long-term culture. . J. Neurosci. Res. . 47 . 3 . 311–21 . 1997 . 9039653 . 10.1002/(SICI)1097-4547(19970201)47:3<311::AID-JNR9>3.0.CO;2-L . 13044525 .
- Porter RH, Eastwood SL, Harrison PJ . Distribution of kainate receptor subunit mRNAs in human hippocampus, neocortex and cerebellum, and bilateral reduction of hippocampal GluR6 and KA2 transcripts in schizophrenia. . Brain Res. . 751 . 2 . 217–31 . 1997 . 9099808 . 10.1016/S0006-8993(96)01404-7 . 9796632 .
- Ripellino JA, Neve RL, Howe JR . Expression and heteromeric interactions of non-N-methyl-D-aspartate glutamate receptor subunits in the developing and adult cerebellum. . Neuroscience . 82 . 2 . 485–97 . 1998 . 9466455 . 10.1016/S0306-4522(97)00296-0 . 23219004 . free .
- Garcia EP, Mehta S, Blair LA, etal . SAP90 binds and clusters kainate receptors causing incomplete desensitization. . Neuron . 21 . 4 . 727–39 . 1998 . 9808460 . 10.1016/S0896-6273(00)80590-5 . 18723258 . free .
- Mehta S, Wu H, Garner CC, Marshall J . Molecular mechanisms regulating the differential association of kainate receptor subunits with SAP90/PSD-95 and SAP97. . J. Biol. Chem. . 276 . 19 . 16092–9 . 2001 . 11279111 . 10.1074/jbc.M100643200 . free .
- Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
- Kohda K, Kamiya Y, Matsuda S, etal . Heteromer formation of delta2 glutamate receptors with AMPA or kainate receptors. . Brain Res. Mol. Brain Res. . 110 . 1 . 27–37 . 2003 . 12573530 . 10.1016/S0169-328X(02)00561-2 .
- Hayes DM, Braud S, Hurtado DE, etal . Trafficking and surface expression of the glutamate receptor subunit, KA2. . Biochem. Biophys. Res. Commun. . 310 . 1 . 8–13 . 2003 . 14511640 . 10.1016/j.bbrc.2003.08.115 .
- Kamm C, Leung J, Joseph S, etal . Refined linkage to the RDP/DYT12 locus on 19q13.2 and evaluation of GRIK5 as a candidate gene. . Mov. Disord. . 19 . 7 . 845–7 . 2004 . 15254951 . 10.1002/mds.20095 . 20276163 .
Notes and References
- Szpirer C, Molne M, Antonacci R, Jenkins NA, Finelli P, Szpirer J, Riviere M, Rocchi M, Gilbert DJ, Copeland NG . The genes encoding the glutamate receptor subunits KA1 and KA2 (GRIK4 and GRIK5) are located on separate chromosomes in human, mouse, and rat . Proc Natl Acad Sci U S A . 91 . 25 . 11849–53 . January 1995 . 7527545 . 45333 . 10.1073/pnas.91.25.11849 . etal. free . 1994PNAS...9111849S .
- Web site: Entrez Gene: GRIK5 glutamate receptor, ionotropic, kainate 5.
- Mehta S, Wu H, Garner CC, Marshall J . Molecular mechanisms regulating the differential association of kainate receptor subunits with SAP90/PSD-95 and SAP97 . J. Biol. Chem. . 276 . 19 . 16092–9 . May 2001 . 11279111 . 10.1074/jbc.M100643200 . free .
- Garcia EP, Mehta S, Blair LA, Wells DG, Shang J, Fukushima T, Fallon JR, Garner CC, Marshall J . SAP90 binds and clusters kainate receptors causing incomplete desensitization . Neuron . 21 . 4 . 727–39 . October 1998 . 9808460 . 10.1016/S0896-6273(00)80590-5 . 18723258 . free .
- Wenthold RJ, Trumpy VA, Zhu WS, Petralia RS . Biochemical and assembly properties of GluR6 and KA2, two members of the kainate receptor family, determined with subunit-specific antibodies . J. Biol. Chem. . 269 . 2 . 1332–9 . January 1994 . 10.1016/S0021-9258(17)42262-9 . 8288598 . free .
- Ripellino JA, Neve RL, Howe JR . Expression and heteromeric interactions of non-N-methyl-D-aspartate glutamate receptor subunits in the developing and adult cerebellum . Neuroscience . 82 . 2 . 485–97 . January 1998 . 9466455 . 10.1016/S0306-4522(97)00296-0. 23219004 . free .