GPSM2 explained

G-protein-signaling modulator 2, also called LGN for its 10 Leucine-Glycine-Asparagine repeats, is a protein that in humans is encoded by the GPSM2 gene.^{[1] [2] [3]}

Function

Heterotrimeric G proteins transduce extracellular signals received by cell surface receptors into integrated cellular responses. GPSM2 belongs to a group of proteins that modulate activation of G proteins (Blumer et al., 2002).[supplied by OMIM]^[3]

Interactions

GPSM2 has been shown to interact with nuclear mitotic apparatus protein 1^[4] and GNAI2.^[5]

Further reading

• Du Q, Stukenberg PT, Macara IG . A mammalian Partner of inscuteable binds NuMA and regulates mitotic spindle organization . Nat. Cell Biol. . 3 . 12 . 1069–75 . 2001 . 11781568 . 10.1038/ncb1201-1069 . 7955950 .
• Marty C, Browning DD, Ye RD . Identification of tetratricopeptide repeat 1 as an adaptor protein that interacts with heterotrimeric G proteins and the small GTPase Ras . Mol. Cell. Biol. . 23 . 11 . 3847–58 . 2003 . 12748287 . 155206 . 10.1128/MCB.23.11.3847-3858.2003 .
• Kaushik R, Yu F, Chia W, Yang X, Bahri S . Subcellular localization of LGN during mitosis: evidence for its cortical localization in mitotic cell culture systems and its requirement for normal cell cycle progression . Mol. Biol. Cell . 14 . 8 . 3144–55 . 2003 . 12925752 . 181556 . 10.1091/mbc.E03-04-0212 .
• Du Q, Macara IG . Mammalian Pins is a conformational switch that links NuMA to heterotrimeric G proteins . Cell . 119 . 4 . 503–16 . 2004 . 15537540 . 10.1016/j.cell.2004.10.028 . 12900159 . free .
• Yasumi M, Sakisaka T, Hoshino T, Kimura T, Sakamoto Y, Yamanaka T, Ohno S, Takai Y . Direct binding of Lgl2 to LGN during mitosis and its requirement for normal cell division . J. Biol. Chem. . 280 . 8 . 6761–5 . 2005 . 15632202 . 10.1074/jbc.C400440200 . free .
• Yang J, Kamide K, Kokubo Y, Takiuchi S, Tanaka C, Banno M, Miwa Y, Yoshii M, Horio T, Okayama A, Tomoike H, Kawano Y, Miyata T . Genetic variations of regulator of G-protein signaling 2 in hypertensive patients and in the general population . J. Hypertens. . 23 . 8 . 1497–505 . 2005 . 16003176 . 10.1097/01.hjh.0000174606.41651.ae . 21266973 .
• Izaki T, Kamakura S, Kohjima M, Sumimoto H . Two forms of human Inscuteable-related protein that links Par3 to the Pins homologues LGN and AGS3 . Biochem. Biophys. Res. Commun. . 341 . 4 . 1001–6 . 2006 . 16458856 . 10.1016/j.bbrc.2006.01.050 .

Notes and References

1. Blumer JB, Chandler LJ, Lanier SM . Expression analysis and subcellular distribution of the two G-protein regulators AGS3 and LGN indicate distinct functionality. Localization of LGN to the midbody during cytokinesis . J. Biol. Chem. . 277 . 18 . 15897–903 . Apr 2002 . 11832491 . 10.1074/jbc.M112185200 . free .
2. Mochizuki N, Cho G, Wen B, Insel PA . Identification and cDNA cloning of a novel human mosaic protein, LGN, based on interaction with G alpha i2 . Gene . 181 . 1–2 . 39–43 . 1996 . 8973305 . 10.1016/S0378-1119(96)00456-8 .
3. Web site: Entrez Gene: GPSM2 G-protein signalling modulator 2 (AGS3-like, C. elegans).
4. Du Q, Stukenberg PT, Macara IG . A mammalian Partner of inscuteable binds NuMA and regulates mitotic spindle organization . Nat. Cell Biol. . 3 . 12 . 1069–75 . Dec 2001 . 11781568 . 10.1038/ncb1201-1069 . 7955950 .
5. Marty C, Browning DD, Ye RD . Identification of tetratricopeptide repeat 1 as an adaptor protein that interacts with heterotrimeric G proteins and the small GTPase Ras . Mol. Cell. Biol. . 23 . 11 . 3847–58 . Jun 2003 . 12748287 . 155206 . 10.1128/MCB.23.11.3847-3858.2003 .