GPR78 explained

GPR78 should not be confused with GRP78.

Probable G-protein coupled receptor 78 is a protein that in humans is encoded by the GPR78 gene.^{[1] [2]}

G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[supplied by OMIM]

Further reading

• van Laar T . The novel MMS-inducible gene Mif1/KIAA0025 is a target of the unfolded protein response pathway . FEBS Lett. . 469 . 1 . 123–31 . 2000 . 10708769 . 10.1016/S0014-5793(00)01253-9 . Schouten T . Hoogervorst E . Van Eck . M . Van Der Eb . AJ . Terleth . C . 6419566 . free.
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . Feingold EA . Grouse LH . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Clark HF . The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment . Genome Res. . 13 . 10 . 2265–70 . 2003 . 12975309 . 10.1101/gr.1293003 . 403697 . Gurney AL . Abaya E . Baker . K . Baldwin . D . Brush . J . Chen . J . Chow . B . Chui . C .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . Wagner L . Feingold EA . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Underwood SL . Association analysis of the chromosome 4p-located G protein-coupled receptor 78 (GPR78) gene in bipolar affective disorder and schizophrenia . Mol. Psychiatry . 11 . 4 . 384–94 . 2006 . 16389273 . 10.1038/sj.mp.4001786 . Christoforou A . Thomson PA . Wray . N R . Tenesa . A . Whittaker . J . Adams . R A . Le Hellard . S . Morris . S W . 12678399 .

Notes and References

1. Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF . Discovery and mapping of ten novel G protein-coupled receptor genes . Gene . 275 . 1 . 83–91 . Sep 2001 . 11574155 . 10.1016/S0378-1119(01)00651-5 .
2. Web site: Entrez Gene: GPR78 G protein-coupled receptor 78.