GPR52 explained

Probable G-protein coupled receptor 52 is a protein that in humans is encoded by the GPR52 gene.^{[1] [2]}

Members of the G protein-coupled receptor (GPR) family play important roles in signal transduction from the external environment to the inside of the cell.[supplied by OMIM]

Cannabidiol, CBD, and O-1918 are Inverse agonist at GPR52.^[3]

Notes and References

1. Sawzdargo M, Nguyen T, Lee DK, Lynch KR, Cheng R, Heng HH, George SR, O'Dowd BF . Identification and cloning of three novel human G protein-coupled receptor genes GPR52, PsiGPR53 and GPR55: GPR55 is extensively expressed in human brain . Brain Research. Molecular Brain Research . 64 . 2 . 193–198 . February 1999 . 9931487 . 10.1016/S0169-328X(98)00277-0 .
2. Web site: Entrez Gene: GPR52 G protein-coupled receptor 52 .
3. Stott LA, Brighton CA, Brown J, Mould R, Bennett KA, Newman R, Currinn H, Autore F, Higueruelo AP, Tehan BG, MacSweeney C, O'Brien MA, Watson SP . Characterisation of inverse agonism of the orphan-G protein-coupled receptor GPR52 by cannabinoid ligands Cannabidiol and O-1918 . Heliyon . 7 . 6 . e07201 . June 2021 . 34189291 . 8219759 . 10.1016/j.heliyon.2021.e07201 . free . 2021Heliy...707201S .