GPR146 explained

G-protein coupled receptor 146 is a protein that in humans is encoded by the GPR146 gene.^[1] The receptor has been shown to bind cholesin/C17orf50, a gut-derived hormone that is secreted from the intestine in response to dietary cholesterol absorption. In response to cholesin binding, GPR146 signaling inhibit cholesterol synthesis. ^[2] Consistent with this interaction, murine genetic disruption of GPR146 lowers serum cholesterol and reduces atherosclerotic aortic lesions.^[3] GPR146 has also been identified as a possible receptor for C-peptide.^[4]

Further reading

• Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, Mortrud MT, Brown A, Rodriguez SS, Weller JR, Wright AC, Bergmann JE, Gaitanaris GA . The G protein-coupled receptor repertoires of human and mouse . Proceedings of the National Academy of Sciences of the United States of America . 100 . 8 . 4903–8 . Apr 2003 . 12679517 . 153653 . 10.1073/pnas.0230374100 . 2003PNAS..100.4903V . free .
• Gloriam DE, Schiöth HB, Fredriksson R . Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship . Biochimica et Biophysica Acta (BBA) - General Subjects . 1722 . 3 . 235–46 . Apr 2005 . 15777626 . 10.1016/j.bbagen.2004.12.001 .

Notes and References

1. Web site: Entrez Gene: GPR146 G protein-coupled receptor 146.
2. Hu X, Chen F, Jia L, Long A, Peng Y, Li X . etal. A gut-derived hormone regulates cholesterol metabolism. . Cell . 2024 . 187 . 7 . 1685-1700.e18 . 38503280 . 10.1016/j.cell.2024.02.024 .
3. Yu H, Rimbert A, Palmer AE, Toyohara T, Xia Y, Xia F . etal. GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis. . Cell . 2019 . 179 . 6 . 1276-1288.e14 . 31778654 . 10.1016/j.cell.2019.10.034 . 6889877 .
4. Yosten GL, Kolar GR, Redlinger LJ, Samson WK . Evidence for an interaction between proinsulin C-peptide and GPR146 . The Journal of Endocrinology . 218 . 2 . B1-8 . 11 July 2013 . 23759446 . 10.1530/JOE-13-0203 . free .