GPCR neuropeptide receptor explained

GPCR neuropeptide receptors are G-protein coupled receptors which bind various neuropeptides. Members include:

• Neuropeptide B/W receptor^[1]
  • NPBWR1
  • NPBWR2
• Neuropeptide FF receptor^[2]
  • NPFFR1
  • NPFFR2
• Neuropeptide S receptor^[3]
  • NPSR1
• Neuropeptide Y receptor^[4]
  • Y₁ - NPY1R
  • Y₂ - NPY2R
  • Y₄ - PPYR1
  • Y₅ - NPY5R

External links

• Web site: G-Protein Coupled Receptors . IUPHAR Database of Receptors and Ion Channels . International Union of Basic and Clinical Pharmacology .

Notes and References

1. Singh G, Davenport AP . Neuropeptide B and W: neurotransmitters in an emerging G-protein-coupled receptor system . Br. J. Pharmacol. . 148 . 8 . 1033–41 . 2006 . 16847439 . 10.1038/sj.bjp.0706825. 1752024 .
2. Elshourbagy NA, Ames RS, Fitzgerald LR, Foley JJ, Chambers JK, Szekeres PG, Evans NA, Schmidt DB, Buckley PT, Dytko GM, Murdock PR, Milligan G, Groarke DA, Tan KB, Shabon U, Nuthulaganti P, Wang DY, Wilson S, Bergsma DJ, Sarau HM . Receptor for the pain modulatory neuropeptides FF and AF is an orphan G protein-coupled receptor . J. Biol. Chem. . 275 . 34 . 25965–71 . 2000 . 10851242 . 10.1074/jbc.M004515200 . free .
3. Vendelin J, Pulkkinen V, Rehn M, Pirskanen A, Räisänen-Sokolowski A, Laitinen A, Laitinen LA, Kere J, Laitinen T . Characterization of GPRA, a novel G protein-coupled receptor related to asthma . Am. J. Respir. Cell Mol. Biol. . 33 . 3 . 262–70 . 2005 . 15947423 . 10.1165/rcmb.2004-0405OC .
4. Larhammar D, Salaneck E . Molecular evolution of NPY receptor subtypes . Neuropeptides . 38 . 4 . 141–51 . 2004 . 15337367 . 10.1016/j.npep.2004.06.002 . 43696257 .