GNAT3 explained

Guanine nucleotide-binding protein G(t) subunit alpha-3, also known as gustducin alpha-3 chain, is a protein subunit that in humans is encoded by the GNAT3 gene.^[1]

Gustducin alpha-3 chain is a subunit of the heterotrimeric G protein gustducin that is responsible for basic taste.

Further reading

• Oldham WM, Van Eps N, Preininger AM . Mechanism of the receptor-catalyzed activation of heterotrimeric G proteins. . Nat. Struct. Mol. Biol. . 13 . 9 . 772–7 . 2006 . 16892066 . 10.1038/nsmb1129 . 290532 . etal.
• Scherer SW, Cheung J, MacDonald JR . Human chromosome 7: DNA sequence and biology. . Science . 300 . 5620 . 767–72 . 2003 . 12690205 . 10.1126/science.1083423 . 2882961. 2003Sci...300..767S . etal.
• Rozengurt N, Wu SV, Chen MC . Colocalization of the alpha-subunit of gustducin with PYY and GLP-1 in L cells of human colon. . Am. J. Physiol. Gastrointest. Liver Physiol. . 291 . 5 . G792-802 . 2006 . 16728727 . 10.1152/ajpgi.00074.2006 . etal.
• Huang L, Shanker YG, Dubauskaite J . Ggamma13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium. . Nat. Neurosci. . 2 . 12 . 1055–62 . 1999 . 10570481 . 10.1038/15981 . 24494794 . etal.
• Hillier LW, Fulton RS, Fulton LA . The DNA sequence of human chromosome 7. . Nature . 424 . 6945 . 157–64 . 2003 . 12853948 . 10.1038/nature01782 . 2003Natur.424..157H . etal. free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2002 . 12477932 . 10.1073/pnas.242603899 . 139241. 2002PNAS...9916899M . etal. free .
• Luttrell LM . Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors. . Mol. Biotechnol. . 39 . 3 . 239–64 . 2008 . 18240029 . 10.1007/s12033-008-9031-1 . 45173229 .
• Margolskee RF, Dyer J, Kokrashvili Z . T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1. . Proc. Natl. Acad. Sci. U.S.A. . 104 . 38 . 15075–80 . 2007 . 17724332 . 10.1073/pnas.0706678104 . 2007PNAS..10415075M . 1986615. etal. free .
• Takami S, Getchell TV, McLaughlin SK . Human taste cells express the G protein alpha-gustducin and neuron-specific enolase. . Brain Res. Mol. Brain Res. . 22 . 1–4 . 193–203 . 1994 . 8015379 . 10.1016/0169-328X(94)90047-7 . etal.
• Jang HJ, Kokrashvili Z, Theodorakis MJ . Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1. . Proc. Natl. Acad. Sci. U.S.A. . 104 . 38 . 15069–74 . 2007 . 17724330 . 10.1073/pnas.0706890104 . 2007PNAS..10415069J . 1986614. etal. free .
• Li X, Staszewski L, Xu H . Human receptors for sweet and umami taste. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 7 . 4692–6 . 2002 . 11917125 . 10.1073/pnas.072090199 . 123709. 2002PNAS...99.4692L . etal. free .
• Fehr J, Meyer D, Widmayer P . Expression of the G-protein alpha-subunit gustducin in mammalian spermatozoa. . J. Comp. Physiol. A . 193 . 1 . 21–34 . 2007 . 17021831 . 10.1007/s00359-006-0168-8 . 25762931 . etal.
• Lambright DG, Noel JP, Hamm HE, Sigler PB . Structural determinants for activation of the alpha-subunit of a heterotrimeric G protein. . Nature . 369 . 6482 . 621–8 . 1994 . 8208289 . 10.1038/369621a0 . 1994Natur.369..621L . 4238569 .

Notes and References

1. Web site: Entrez Gene: guanine nucleotide binding protein.