GNAS-AS1 explained

In molecular biology, GNAS antisense RNA (non-protein coding), also known as GNAS-AS1, is a long non-coding RNA.It is antisense to the GNAS gene. It is an imprinted gene, expressed only from the paternal allele, suggesting that it may have a role in suppression of the paternal NESP55 allele encoded by GNAS.^[1]

See also

• Long noncoding RNA

Further reading

• Tobi EW, Lumey LH, Talens RP . DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific. . Hum. Mol. Genet. . 18 . 21 . 4046–4053 . 2009 . 19656776 . 10.1093/hmg/ddp353 . 2758137. etal.
• Kimura K, Wakamatsu A, Suzuki Y . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129. etal.
• Hayward BE, Bonthron DT . An imprinted antisense transcript at the human GNAS1 locus. . Hum. Mol. Genet. . 9 . 5 . 835–841 . 2000 . 10749992 . 10.1093/hmg/9.5.835. free .
• Wroe SF, Kelsey G, Skinner JA . An imprinted transcript, antisense to Nesp, adds complexity to the cluster of imprinted genes at the mouse Gnas locus. . Proc. Natl. Acad. Sci. U.S.A. . 97 . 7 . 3342–3346 . 2000 . 10716699 . 10.1073/pnas.050015397 . 16241. etal. free .
• Li T, Vu TH, Zeng ZL . Tissue-specific expression of antisense and sense transcripts at the imprinted Gnas locus. . Genomics . 69 . 3 . 295–304 . 2000 . 11056047 . 10.1006/geno.2000.6337 . etal.
• Williamson CM, Skinner JA, Kelsey G, Peters J . Alternative non-coding splice variants of Nespas, an imprinted gene antisense to Nesp in the Gnas imprinting cluster. . Mamm. Genome . 13 . 2 . 74–79 . 2002 . 11889554 . 10.1007/s00335-001-2102-2 . 22736144 .

Notes and References

1. Hayward BE, Bonthron DT . An imprinted antisense transcript at the human GNAS1 locus. . Hum Mol Genet . 2000 . 9 . 5 . 835–841 . 10749992 . 10.1093/hmg/9.5.835. free .