GIMAP5 explained

GTPase IMAP family member 5 is an enzyme that in humans is encoded by the GIMAP5 gene.^[1]

This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1.^[2]

Further reading

• Dahéron L, Zenz T, Siracusa LD . Molecular cloning of Ian4: a BCR/ABL-induced gene that encodes an outer membrane mitochondrial protein with GTP-binding activity. . Nucleic Acids Res. . 29 . 6 . 1308–16 . 2001 . 11238997 . 10.1093/nar/29.6.1308 . 29751 . etal.
• Stamm O, Krücken J, Schmitt-Wrede HP . Human ortholog to mouse gene imap38 encoding an ER-localizable G-protein belongs to a gene family clustered on chromosome 7q32-36. . Gene . 282 . 1–2 . 159–67 . 2002 . 11814688 . 10.1016/S0378-1119(01)00837-X . etal.
• Cambot M, Aresta S, Kahn-Perlès B . Human immune associated nucleotide 1: a member of a new guanosine triphosphatase family expressed in resting T and B cells . Blood . 99 . 9 . 3293–301 . 2002 . 11964296 . 10.1182/blood.V99.9.3293 . etal. free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Scherer SW, Cheung J, MacDonald JR . Human chromosome 7: DNA sequence and biology . Science . 300 . 5620 . 767–72 . 2003 . 12690205 . 2882961 . 10.1126/science.1083423 . 2003Sci...300..767S . etal.
• Sandal T, Aumo L, Hedin L . Irod/Ian5: an inhibitor of gamma-radiation- and okadaic acid-induced apoptosis . Mol. Biol. Cell . 14 . 8 . 3292–304 . 2004 . 12925764 . 10.1091/mbc.E02-10-0700 . 181568 . etal.
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Zenz T, Roessner A, Thomas A . hIan5: the human ortholog to the rat Ian4/Iddm1/lyp is a new member of the Ian family that is overexpressed in B-cell lymphoid malignancies . Genes Immun. . 5 . 2 . 109–16 . 2004 . 14724691 . 10.1038/sj.gene.6364044 . 750615 . etal.
• Krücken J, Schroetel RM, Müller IU . Comparative analysis of the human gimap gene cluster encoding a novel GTPase family . Gene . 341 . 291–304 . 2005 . 15474311 . 10.1016/j.gene.2004.07.005 . etal.
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Hellquist A, Zucchelli M, Kivinen K . The human GIMAP5 gene has a common polyadenylation polymorphism increasing risk to systemic lupus erythematosus . J. Med. Genet. . 44 . 5 . 314–21 . 2007 . 17220214 . 10.1136/jmg.2006.046185 . 2597989 . etal.
• Dalberg U, Markholst H, Hornum L . Both Gimap5 and the diabetogenic BBDP allele of Gimap5 induce apoptosis in T cells . Int. Immunol. . 19 . 4 . 447–53 . 2007 . 17369194 . 10.1093/intimm/dxm009 . free .
• Shin JH, Janer M, McNeney B . IA-2 autoantibodies in incident type I diabetes patients are associated with a polyadenylation signal polymorphism in GIMAP5 . Genes Immun. . 8 . 6 . 503–12 . 2007 . 17641683 . 10.1038/sj.gene.6364413 . etal. free .

Notes and References

1. Web site: Entrez Gene: GIMAP5 GTPase, IMAP family member 5.
2. Web site: Entrez Gene: GIMAP5 GTPase, IMAP family member 5.