GIMAP4 explained

GTPase IMAP family member 4 is an enzyme that in humans is encoded by the GIMAP4 gene.^{[1] [2] [3]}

This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. The encoded protein of this gene may be negatively regulated by T-cell acute lymphocytic leukemia 1 (TAL1). In humans, the IAN subfamily genes are located in a cluster at 7q36.1.^[3]

Further reading

• Dominguez O, Ashhab Y, Sabater L . Cloning of ARE-containing genes by AU-motif-directed display. . Genomics . 54 . 2 . 278–86 . 1999 . 9828130 . 10.1006/geno.1998.5548 . etal.
• Dias Neto E, Correa RG, Verjovski-Almeida S . Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. . Proc. Natl. Acad. Sci. U.S.A. . 97 . 7 . 3491–6 . 2000 . 10737800 . 10.1073/pnas.97.7.3491 . 16267 . 2000PNAS...97.3491D . etal. free .
• Stamm O, Krücken J, Schmitt-Wrede HP . Human ortholog to mouse gene imap38 encoding an ER-localizable G-protein belongs to a gene family clustered on chromosome 7q32-36. . Gene . 282 . 1–2 . 159–67 . 2002 . 11814688 . 10.1016/S0378-1119(01)00837-X . etal.
• Cambot M, Aresta S, Kahn-Perlès B . Human immune associated nucleotide 1: a member of a new guanosine triphosphatase family expressed in resting T and B cells. . Blood . 99 . 9 . 3293–301 . 2002 . 11964296 . 10.1182/blood.V99.9.3293 . etal. free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Scherer SW, Cheung J, MacDonald JR . Human chromosome 7: DNA sequence and biology. . Science . 300 . 5620 . 767–72 . 2003 . 12690205 . 2882961 . 10.1126/science.1083423 . 2003Sci...300..767S . etal.
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Nitta T, Nasreen M, Seike T . IAN family critically regulates survival and development of T lymphocytes. . PLOS Biol. . 4 . 4 . e103 . 2006 . 16509771 . 10.1371/journal.pbio.0040103 . 1393758 . etal . free .

Notes and References

1. Krucken J, Schroetel RM, Muller IU, Saidani N, Marinovski P, Benten WP, Stamm O, Wunderlich F . Comparative analysis of the human gimap gene cluster encoding a novel GTPase family . Gene . 341 . 291–304 . Oct 2004 . 15474311 . 10.1016/j.gene.2004.07.005 .
2. Filen JJ, Filen S, Moulder R, Tuomela S, Ahlfors H, West A, Kouvonen P, Kantola S, Bjorkman M, Katajamaa M, Rasool O, Nyman TA, Lahesmaa R . Quantitative proteomics reveals GIMAP family proteins 1 and 4 to be differentially regulated during human T helper cell differentiation . Mol Cell Proteomics . 8 . 1 . 32–44 . Jan 2009 . 18701445 . 2621005 . 10.1074/mcp.M800139-MCP200 . free .
3. Web site: Entrez Gene: GIMAP4 GTPase, IMAP family member 4.