GHMP kinase family explained

In molecular biology, the GHMP kinase family is a family of kinase enzymes. Members of this family include homoserine kinases, galactokinases, and mevalonate kinases. These kinases make up the GHMP kinase superfamily of ATP-dependent enzymes.^[1] These enzymes are involved in the biosynthesis of isoprenes and amino acids as well as in carbohydrate metabolism. These enzymes contain, in their N-terminal section, a conserved Gly/Ser-rich region which is probably involved in the binding of ATP.^{[2] [3]} The C-terminal domain of homoserine kinase has a central alpha-beta plait fold and an insertion of four helices, which, together with the N-terminal fold, creates a novel nucleotide binding fold.^[4]

Notes and References

1. Bork P, Sander C, Valencia A . Convergent evolution of similar enzymatic function on different protein folds: the hexokinase, ribokinase, and galactokinase families of sugar kinases . Protein Sci. . 2 . 1 . 31–40 . January 1993 . 8382990 . 2142297 . 10.1002/pro.5560020104 .
2. Tsay YH, Robinson GW . Cloning and characterization of ERG8, an essential gene of Saccharomyces cerevisiae that encodes phosphomevalonate kinase . Mol. Cell. Biol. . 11 . 2 . 620–31 . February 1991 . 1846667 . 359713 . 10.1128/MCB.11.2.620.
3. Lee M, Leustek T . Identification of the gene encoding homoserine kinase from Arabidopsis thaliana and characterization of the recombinant enzyme derived from the gene . Arch. Biochem. Biophys. . 372 . 1 . 135–42 . December 1999 . 10562426 . 10.1006/abbi.1999.1481 .
4. Zhou T, Daugherty M, Grishin NV, Osterman AL, Zhang H . Structure and mechanism of homoserine kinase: prototype for the GHMP kinase superfamily . Structure . 8 . 12 . 1247–57 . December 2000 . 11188689 . 10.1016/s0969-2126(00)00533-5. free .