GDI2 explained

Rab GDP dissociation inhibitor beta is a protein that in humans is encoded by the GDI2 gene.^{[1] [2]}

GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI2 is ubiquitously expressed. The GDI2 gene contains many repetitive elements indicating that it may be prone to inversion/deletion rearrangements.^[2]

Further reading

• Dawson SJ, White LA . Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin. . J. Infect. . 24 . 3 . 317–20 . 1992 . 1602151 . 10.1016/S0163-4453(05)80037-4 .
• Shisheva A, Südhof TC, Czech MP . Cloning, characterization, and expression of a novel GDP dissociation inhibitor isoform from skeletal muscle. . Mol. Cell. Biol. . 14 . 5 . 3459–68 . 1994 . 7513052 . 10.1128/mcb.14.5.3459. 358710 .
• Bächner D, Sedlacek Z, Korn B . Expression patterns of two human genes coding for different rab GDP-dissociation inhibitors (GDIs), extremely conserved proteins involved in cellular transport. . Hum. Mol. Genet. . 4 . 4 . 701–8 . 1995 . 7543319 . 10.1093/hmg/4.4.701 . etal.
• Nishimura N, Goji J, Nakamura H . Cloning of a brain-type isoform of human Rab GDI and its expression in human neuroblastoma cell lines and tumor specimens. . Cancer Res. . 55 . 22 . 5445–50 . 1995 . 7585614 . etal.
• Shisheva A, Buxton J, Czech MP . Differential intracellular localizations of GDP dissociation inhibitor isoforms. Insulin-dependent redistribution of GDP dissociation inhibitor-2 in 3T3-L1 adipocytes. . J. Biol. Chem. . 269 . 39 . 23865–8 . 1994 . 10.1016/S0021-9258(19)51016-X . 7929030 . free .
• Shisheva A, Doxsey SJ, Buxton JM, Czech MP . Pericentriolar targeting of GDP-dissociation inhibitor isoform 2. . Eur. J. Cell Biol. . 68 . 2 . 143–58 . 1996 . 8575461 .
• Shisheva A, Chinni SR, DeMarco C . General role of GDP dissociation inhibitor 2 in membrane release of Rab proteins: modulations of its functional interactions by in vitro and in vivo structural modifications. . Biochemistry . 38 . 36 . 11711–21 . 1999 . 10512627 . 10.1021/bi990200r .
• Caillol N, Pasqualini E, Lloubes R, Lombardo D . Impairment of bile salt-dependent lipase secretion in human pancreatic tumoral SOJ-6 cells. . J. Cell. Biochem. . 79 . 4 . 628–47 . 2000 . 10996854 . 10.1002/1097-4644(20001215)79:4<628::AID-JCB120>3.0.CO;2-T . 11614620 .
• Book: Weitzdoerfer R, Stolzlechner D, Dierssen M . Reduction of nucleoside diphosphate kinase B, Rab GDP- dissociation inhibitor beta and histidine triad nucleotide-binding protein in fetal Down Syndrome brain . Protein Expression in Down Syndrome Brain . Journal of Neural Transmission. Supplementum . 61 . 347–59 . 2002 . 11771757 . 10.1007/978-3-7091-6262-0_29. 978-3-211-83704-7 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Shin BK, Wang H, Yim AM . Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function. . J. Biol. Chem. . 278 . 9 . 7607–16 . 2003 . 12493773 . 10.1074/jbc.M210455200 . etal. free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Theodorescu D, Sapinoso LM, Conaway MR . Reduced expression of metastasis suppressor RhoGDI2 is associated with decreased survival for patients with bladder cancer. . Clin. Cancer Res. . 10 . 11 . 3800–6 . 2004 . 15173088 . 10.1158/1078-0432.CCR-03-0653 . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Bruneel A, Labas V, Mailloux A . Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis. . Proteomics . 5 . 15 . 3876–84 . 2006 . 16130169 . 10.1002/pmic.200401239 . 26007149 . etal.
• Rual JF, Venkatesan K, Hao T . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 . etal.
• Hu LD, Zou HF, Zhan SX, Cao KM . Biphasic expression of RhoGDI2 in the progression of breast cancer and its negative relation with lymph node metastasis. . Oncol. Rep. . 17 . 6 . 1383–9 . 2007 . 17487395 . 10.3892/or.17.6.1383. free .
• Sun ZL, Zhu Y, Wang FQ . Serum proteomic-based analysis of pancreatic carcinoma for the identification of potential cancer biomarkers. . Biochim. Biophys. Acta . 1774 . 6 . 764–71 . 2007 . 17507299 . 10.1016/j.bbapap.2007.04.001 . etal.

Notes and References

1. Sedlacek Z, Munstermann E, Mincheva A, Lichter P, Poustka A . The human rab GDI beta gene with long retroposon-rich introns maps to 10p15 and its pseudogene to 7p11-p13 . Mamm Genome . 9 . 1 . 78–80 . Feb 1998 . 9434952 . 10.1007/s003359900685 . 36441100 .
2. Web site: Entrez Gene: GDI2 GDP dissociation inhibitor 2.