GBP1 explained

Interferon-induced guanylate-binding protein 1 is a protein that in humans is encoded by the GBP1 gene.^{[1] [2]} It belongs to the dynamin superfamily of large GTPases.^[3]

Function

Guanylate binding protein expression is induced by interferon. Guanylate binding proteins are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3.^[2]

Further reading

• Anderson NL, Anderson NG . The human plasma proteome: history, character, and diagnostic prospects. . Mol. Cell. Proteomics . 1 . 11 . 845–67 . 2003 . 12488461 . 10.1074/mcp.R200007-MCP200. free .
• Naschberger E, Bauer M, Stürzl M . Human guanylate binding protein-1 (hGBP-1) characterizes and establishes a non-angiogenic endothelial cell activation phenotype in inflammatory diseases. . Adv. Enzyme Regul. . 45 . 215–27 . 2006 . 16005050 . 10.1016/j.advenzreg.2005.02.011 .
• Cheng YS, Patterson CE, Staeheli P . Interferon-induced guanylate-binding proteins lack an N(T)KXD consensus motif and bind GMP in addition to GDP and GTP . Mol. Cell. Biol. . 11 . 9 . 4717–25 . 1991 . 1715024 . 10.1128/MCB.11.9.4717. 361367 .
• Nantais DE, Schwemmle M, Stickney JT . Prenylation of an interferon-gamma-induced GTP-binding protein: the human guanylate binding protein, huGBP1 . J. Leukoc. Biol. . 60 . 3 . 423–31 . 1996 . 8830800 . 10.1002/jlb.60.3.423. 33727864 . etal.
• Saunders NA, Smith RJ, Jetten AM . Regulation of guanylate-binding protein expression in interferon-gamma-treated human epidermal keratinocytes and squamous cell carcinoma cells . J. Invest. Dermatol. . 112 . 6 . 977–83 . 1999 . 10383748 . 10.1046/j.1523-1747.1999.00611.x . free .
• Prakash B, Praefcke GJ, Renault L . Structure of human guanylate-binding protein 1 representing a unique class of GTP-binding proteins . Nature . 403 . 6769 . 567–71 . 2000 . 10676968 . 10.1038/35000617 . 2000Natur.403..567P . 4431592 . etal.
• Kumar S, Li Q, Dua A . Messenger ribonucleic acid encoding interferon-inducible guanylate binding protein 1 is induced in human endometrium within the putative window of implantation . J. Clin. Endocrinol. Metab. . 86 . 6 . 2420–7 . 2001 . 10.1210/jcem.86.6.7534 . 11397834 . etal. free .
• Guenzi E, Töpolt K, Cornali E . The helical domain of GBP-1 mediates the inhibition of endothelial cell proliferation by inflammatory cytokines . EMBO J. . 20 . 20 . 5568–77 . 2001 . 11598000 . 10.1093/emboj/20.20.5568 . 125279 . etal.
• Lubeseder-Martellato C, Guenzi E, Jörg A . Guanylate-Binding Protein-1 Expression Is Selectively Induced by Inflammatory Cytokines and Is an Activation Marker of Endothelial Cells during Inflammatory Diseases . Am. J. Pathol. . 161 . 5 . 1749–59 . 2002 . 12414522 . 10.1016/S0002-9440(10)64452-5. 1850787 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Adkins JN, Varnum SM, Auberry KJ . Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry . Mol. Cell. Proteomics . 1 . 12 . 947–55 . 2003 . 12543931 . 10.1074/mcp.M200066-MCP200. etal. free .
• Guenzi E, Töpolt K, Lubeseder-Martellato C . The guanylate binding protein-1 GTPase controls the invasive and angiogenic capability of endothelial cells through inhibition of MMP-1 expression . EMBO J. . 22 . 15 . 3772–82 . 2003 . 12881412 . 10.1093/emboj/cdg382 . 169055 . etal.
• Naschberger E, Werner T, Vicente AB . Nuclear factor-kappaB motif and interferon-alpha-stimulated response element co-operate in the activation of guanylate-binding protein-1 expression by inflammatory cytokines in endothelial cells . Biochem. J. . 379 . Pt 2 . 409–20 . 2004 . 14741045 . 10.1042/BJ20031873 . 1224089 . etal.
• Gerhard DS, Wagner L, Feingold EA . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Praefcke GJ, Kloep S, Benscheid U . Identification of residues in the human guanylate-binding protein 1 critical for nucleotide binding and cooperative GTP hydrolysis . J. Mol. Biol. . 344 . 1 . 257–69 . 2004 . 15504415 . 10.1016/j.jmb.2004.09.026 . etal.
• Modiano N, Lu YE, Cresswell P . Golgi targeting of human guanylate-binding protein-1 requires nucleotide binding, isoprenylation, and an IFN-γ-inducible cofactor . Proc. Natl. Acad. Sci. U.S.A. . 102 . 24 . 8680–5 . 2005 . 15937107 . 10.1073/pnas.0503227102 . 1150846 . 2005PNAS..102.8680M . free .
• Ghosh A, Praefcke GJ, Renault L . How guanylate-binding proteins achieve assembly-stimulated processive cleavage of GTP to GMP . Nature . 440 . 7080 . 101–4 . 2006 . 16511497 . 10.1038/nature04510 . 2006Natur.440..101G . 4405773 . etal.

Notes and References

1. Strehlow I, Lohmann-Matthes ML, Decker T . The interferon-inducible GBP1 gene: structure and mapping to human chromosome 1 . Gene . 144 . 2 . 295–9 . Aug 1994 . 7518790 . 10.1016/0378-1119(94)90393-X .
2. Web site: Entrez Gene: GBP1 guanylate binding protein 1, interferon-inducible, 67kDa.
3. Praefcke GJ, McMahon HT . The dynamin superfamily: universal membrane tubulation and fission molecules? . Nat. Rev. Mol. Cell Biol. . 5 . 2 . 133–47 . February 2004 . 15040446 . 10.1038/nrm1313. 6305282 .