GABRQ explained

Gamma-aminobutyric acid receptor subunit theta is a protein that in humans is encoded by the GABRQ gene.^{[1] [2]} The protein encoded by this gene is a subunit of the GABAA receptor.

The θ subunit has highest sequence similarity with the β1 subunit.^[2] This subunit coassembles with:

• α2, β1, and γ1^[2]
• α3 and β1^[3]
• α3, β1, and ε.^[3]

Further reading

• Whiting PJ, Bonnert TP, McKernan RM . Molecular and functional diversity of the expanding GABA-A receptor gene family . Ann. N. Y. Acad. Sci. . 868 . 645–653 . 1999 . 1 . 10414349 . 10.1111/j.1749-6632.1999.tb11341.x . 1999NYASA.868..645W . 13130259 . etal.
• Craddock N, Jones L, Jones IR . Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype . Mol. Psychiatry . 15 . 2 . 146–153 . 2010 . 19078961 . 10.1038/mp.2008.66 . etal . 3967096.
• Sinkkonen ST, Hanna MC, Kirkness EF, Korpi ER . GABA(A) receptor epsilon and theta subunits display unusual structural variation between species and are enriched in the rat locus ceruleus . J. Neurosci. . 20 . 10 . 3588–3595 . 2000 . 10804200 . 10.1523/jneurosci.20-10-03588.2000. 6772669 . free .
• Gerhard DS, Wagner L, Feingold EA . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–2127 . 2004 . 15489334 . 528928 . 10.1101/gr.2596504 . etal.
• Gratacòs M, Costas J, de Cid R . Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment . Am. J. Med. Genet. B Neuropsychiatr. Genet. . 150B . 6 . 808–816 . 2009 . 19086053 . 10.1002/ajmg.b.30902 . etal. free .
• Bonnert TP, McKernan RM, Farrar S . θ, a novel γ-aminobutyric acid type A receptor subunit . Proc. Natl. Acad. Sci. U.S.A. . 96 . 17 . 9891–9896 . 1999 . 10449790 . 22306 . 10.1073/pnas.96.17.9891 . 1999PNAS...96.9891B . etal. free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–16903 . 2002 . 12477932 . 139241 . 10.1073/pnas.242603899 . 2002PNAS...9916899M . etal. free .
• Fernandez F, Esposito T, Lea RA . Investigation of Gamma-aminobutyric acid (GABA) A receptors genes and migraine susceptibility . BMC Med. Genet. . 9. 109 . 2008 . 19087248 . 2615754 . 10.1186/1471-2350-9-109 . etal . free .
• Tabakoff B, Saba L, Printz M . Genetical genomic determinants of alcohol consumption in rats and humans . BMC Biol. . 7. 70 . 2009 . 19874574 . 2777866 . 10.1186/1741-7007-7-70 . etal . free .

Notes and References

1. Sinkkonen ST, Hanna MC, Kirkness EF, Korpi ER . GABA(A) receptor epsilon and theta subunits display unusual structural variation between species and are enriched in the rat locus ceruleus . J. Neurosci. . 20 . 10 . 3588–3595 . 15 May 2000. 10804200 . 10.1523/jneurosci.20-10-03588.2000 . 6772669 . free .
2. Bonnert TP, McKernan RM, Farrar S, le Bourdellès B, Heavens RP, Smith DW, Hewson L, Rigby MR, Sirinathsinghji DJ, Brown N, Wafford KA, Whiting PJ . θ, a novel γ-aminobutyric acid type A receptor subunit . Proc. Natl. Acad. Sci. U.S.A. . 96 . 17 . 9891–9896 . August 1999 . 10449790 . 22306 . 10.1073/pnas.96.17.9891 . 1999PNAS...96.9891B . free .
3. Ranna M, Sinkkonen ST, Möykkynen T, Uusi-Oukari M, Korpi ER . Impact of ε and θ subunits on pharmacological properties of α3β1 GABAA receptors expressed in Xenopus oocytes . BMC Pharmacol. . 6. 1 . 2006 . 16412217 . 1363348 . 10.1186/1471-2210-6-1 . free .