GABRP explained

Gamma-aminobutyric acid receptor subunit pi is a protein that in humans is encoded by the GABRP gene.^{[1] [2]}

The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. The subunit encoded by this gene is expressed in several non-neuronal tissues including the uterus and ovaries. This subunit can assemble with known GABA A receptor subunits, and the presence of this subunit alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone.^[2]

See also

• GABAA receptor

Further reading

• Mehta AK, Ticku MK . An update on GABAA receptors. . Brain Res. Brain Res. Rev. . 29 . 2–3 . 196–217 . 1999 . 10209232 . 10.1016/S0165-0173(98)00052-6 . 34393842 .
• Zafrakas M, Chorovicer M, Klaman I . Systematic characterisation of GABRP expression in sporadic breast cancer and normal breast tissue . Int. J. Cancer . 118 . 6 . 1453–1459 . 2007 . 16187283 . 10.1002/ijc.21517 . 21983109 . etal.
• Petryshen TL, Middleton FA, Tahl AR . Genetic investigation of chromosome 5q GABAA receptor subunit genes in schizophrenia . Mol. Psychiatry . 10 . 12 . 1074–1088, 1057 . 2006 . 16172613 . 10.1038/sj.mp.4001739 . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–2127 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–45 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Galey D, Becker K, Haughey N . Differential transcriptional regulation by human immunodeficiency virus type 1 and gp120 in human astrocytes . J. Neurovirol. . 9 . 3 . 358–371 . 2003 . 12775419 . 10.1080/13550280390201119 . 22016092 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–16903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . etal . 2002PNAS...9916899M. free .
• Neelands TR, Macdonald RL . Incorporation of the pi subunit into functional gamma-aminobutyric Acid(A) receptors . Mol. Pharmacol. . 56 . 3 . 598–610 . 1999 . 10462548 . 10.1124/mol.56.3.598.
• Taylor PM, Thomas P, Gorrie GH . Identification of amino acid residues within GABA(A) receptor beta subunits that mediate both homomeric and heteromeric receptor expression . J. Neurosci. . 19 . 15 . 6360–6371 . 1999 . 10414965 . 10.1523/jneurosci.19-15-06360.1999. etal . 6782825.

Notes and References

1. Hedblom E, Kirkness EF . A novel class of GABAA receptor subunit in tissues of the reproductive system . J Biol Chem . 272 . 24 . 15346–15350 . Jul 1997 . 9182563 . 10.1074/jbc.272.24.15346 . free .
2. Web site: Entrez Gene: GABRP gamma-aminobutyric acid (GABA) A receptor, pi.