GABRG1 explained

Gamma-aminobutyric acid receptor subunit gamma-1 is a protein that in humans is encoded by the GABRG1 gene.^[1] The protein encoded by this gene is a subunit of the GABAA receptor.^[2]

Variants of this gene may be associated with alcohol dependence.^[3]

Further reading

• Nymann-Andersen J, Wang H, Chen L . Subunit specificity and interaction domain between GABA(A) receptor-associated protein (GABARAP) and GABA(A) receptors. . J. Neurochem. . 80 . 5 . 815–823 . 2002 . 11948245 . 10.1046/j.0022-3042.2002.00762.x . 38049055 . etal.
• Iwakiri M, Mizukami K, Ikonomovic MD . An immunohistochemical study of GABA A receptor gamma subunits in Alzheimer's disease hippocampus: relationship to neurofibrillary tangle progression. . Neuropathology . 29 . 3 . 263–269 . 2009 . 19019179 . 10.1111/j.1440-1789.2008.00978.x . 3078755. etal.
• Craddock N, Jones L, Jones IR . Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype . Mol. Psychiatry . 15 . 2 . 146–153 . 2010 . 19078961 . 3967096 . 10.1038/mp.2008.66 . etal.
• Ray LA, Hutchison KE . Associations among GABRG1, level of response to alcohol, and drinking behaviors. . Alcohol. Clin. Exp. Res. . 33 . 8 . 1382–1390 . 2009 . 19426171 . 10.1111/j.1530-0277.2009.00968.x . 2965732 .
• Ittiwut C, Listman J, Mutirangura A . Interpopulation linkage disequilibrium patterns of GABRA2 and GABRG1 genes at the GABA cluster locus on human chromosome 4 . Genomics . 91 . 1 . 61–69 . 2008 . 17976953 . 10.1016/j.ygeno.2007.08.007 . 2709929 . etal.
• Gratacòs M, Costas J, de Cid R . Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment . Am. J. Med. Genet. B Neuropsychiatr. Genet. . 150B . 6 . 808–816 . 2009 . 19086053 . 10.1002/ajmg.b.30902 . 44524739 . etal.
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–45 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Bonnert TP, McKernan RM, Farrar S . theta, a novel gamma-aminobutyric acid type A receptor subunit . Proc. Natl. Acad. Sci. U.S.A. . 96 . 17 . 9891–9896 . 1999 . 10449790 . 10.1073/pnas.96.17.9891 . 22306 . 1999PNAS...96.9891B . etal. free .
• Guilmatre A, Dubourg C, Mosca AL . Recurrent rearrangements in synaptic and neurodevelopmental genes and shared biologic pathways in schizophrenia, autism, and mental retardation . Arch. Gen. Psychiatry . 66 . 9 . 947–956 . 2009 . 19736351 . 10.1001/archgenpsychiatry.2009.80 . 2958844 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–16903 . 2002 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Ma DQ, Whitehead PL, Menold MM . Identification of significant association and gene-gene interaction of GABA receptor subunit genes in autism . Am. J. Hum. Genet. . 77 . 3 . 377–388 . 2005 . 16080114 . 10.1086/433195 . 1226204 . etal.
• Covault J, Gelernter J, Jensen K . Markers in the 5'-region of GABRG1 associate to alcohol dependence and are in linkage disequilibrium with markers in the adjacent GABRA2 gene . Neuropsychopharmacology . 33 . 4 . 837–848 . 2008 . 17507911 . 10.1038/sj.npp.1301456 . 2743531 . etal.
• Enoch MA, Hodgkinson CA, Yuan Q . GABRG1 and GABRA2 as independent predictors for alcoholism in two populations . Neuropsychopharmacology . 34 . 5 . 1245–1254 . 2009 . 18818659 . 10.1038/npp.2008.171 . 2656604 . etal.
• Wilcox AS, Warrington JA, Gardiner K . Human chromosomal localization of genes encoding the gamma 1 and gamma 2 subunits of the gamma-aminobutyric acid receptor indicates that members of this gene family are often clustered in the genome . Proc. Natl. Acad. Sci. U.S.A. . 89 . 13 . 5857–5861 . 1992 . 1321425 . 10.1073/pnas.89.13.5857 . 49396 . 1992PNAS...89.5857W . etal. free .

Notes and References

1. Wilcox AS, Warrington JA, Gardiner K, Berger R, Whiting P, Altherr MR, Wasmuth JJ, Patterson D, Sikela JM . Human chromosomal localization of genes encoding the gamma 1 and gamma 2 subunits of the gamma-aminobutyric acid receptor indicates that members of this gene family are often clustered in the genome . Proc. Natl. Acad. Sci. U.S.A. . 89 . 13 . 5857–5861 . July 1992 . 1321425 . 49396 . 10.1073/pnas.89.13.5857 . 1992PNAS...89.5857W . free .
2. Hevers W, Lüddens H . The diversity of GABAA receptors. Pharmacological and electrophysiological properties of GABAA channel subtypes . Mol. Neurobiol. . 18 . 1 . 35–86 . August 1998 . 9824848 . 10.1007/BF02741459 . 32359279 .
3. Ittiwut C, Listman J, Mutirangura A, Malison R, Covault J, Kranzler HR, Sughondhabirom A, Thavichachart N, Gelernter J . Interpopulation linkage disequilibrium patterns of GABRA2 and GABRG1 genes at the GABA cluster locus on human chromosome 4 . Genomics . 91 . 1 . 61–69 . January 2008 . 17976953 . 10.1016/j.ygeno.2007.08.007 . 2709929 .