| Fred Nesser | |
| Birth Date: | September 10, 1897 |
| Birth Place: | Columbus, Ohio, U.S. |
| Death Place: | Columbus, Ohio, U.S. |
| Height Ft: | 6 |
| Height In: | 5 |
| Weight Lbs: | 250 |
| Position1: | End, Fullback, Tackle |
| College: | None |
| Pfr: | NessFr21 |
| Databasefootball: | NESSEFRE01 |
| Playing Years1: | 1909–1921 |
| Playing Team1: | Columbus Panhandles |
Frederick W. Nesser (September 10, 1897 – July 2, 1967) was a professional American football player in the "Ohio League" and the early National Football League (NFL) for the Columbus Panhandles. He was also a member of the Nesser Brothers, a group consisting of seven brothers who made-up the most famous football family in the United States from 1907 until the mid-1920s. He was the tallest and biggest of the football-playing brothers at six feet five inches and 250 pounds. He played mostly tackle or end, but sometimes he lined up in the backfield, to provide blocking.
Fred also was a professional boxer and a legitimate contender for the heavyweight title, held by Jess Willard. However, in 1915, a broken wrist ended his boxing career.
Around 1987 Fred's daughter, Vera, tried to get the city of Columbus to name a street for the Nesser Brothers. Her request was turned down.