François de Bourbon, Duke of Châtellerault (1492 – 13 September 1515) was a French prince du sang from the House of Bourbon-Montpensier, a cadet branch of the House of Bourbon (itself a cadet branch of the Capetian dynasty). He was the brother of Charles III, Duke of Bourbon (also known as The Constable of Bourbon).
François de Bourbon was the third and youngest son of Gilbert de Bourbon, the Count of Montpensier, and Clara Gonzaga. François, as duke of Châtellerault, attended the coronation of Francis I of France as a representative of the Duke of Guyenne. François was killed in action on 13 September 1515 at the Battle of Marignano against the Swiss.