| Type: | Bishop |
| Honorific-Prefix: | Most Reverend |
| Francesco Brusco | |
| Bishop of Lettere-Gragnano | |
| Church: | Catholic Church |
| Diocese: | Diocese of Lettere-Gragnano |
| Term: | 1599–1625 |
| Predecessor: | Giovanni Leonardo Bottiglieri |
| Successor: | Andrea Caputo |
| Death Date: | 1625 |
Francesco Brusco (died 1625) was a Roman Catholic prelate who served as Bishop of Lettere-Gragnano (1599–1625).
On 27 September 1599, Francesco Brusco was appointed during the papacy of Pope Clement VIII as Bishop of Lettere-Gragnano.He served as Bishop of Lettere-Gragnano until his death in 1625.