| Post: | First Lady of the Syrian Arab Republic السيدة الأولى للجمهورية العربية السورية |
| Insignia: | Coat_of_arms_of_Syria.svg |
| Insigniasize: | 100px |
| Insigniacaption: | Coat of arms of Syria |
| Incumbent: | Asma al-Assad |
| Incumbentsince: | 13 December 2000 |
| Residence: | People's Palace and Tishreen Palace, Damascus |
| Termlength: | Seven years, renewable once |
| Formation: | 17 August 1943 |
| Inaugural: | Bahira al-Dalati (wife of Shukri al-Quwatli) |
First Lady of Syria is a title attributed to the spouse of the incumbent president of Syria (currently Bashar al-Assad). For the past 51 years, two consecutive first ladies have come from the same ruling family, the Al-Assad family.
| Name | Term Begins | Term Ends | Incumbent President | |
|---|---|---|---|---|
| Bahira al-Dalati[1] | 17 August 1943 | 30 May 1949 | Shukri al-Quwatli | |
| Nouran al-Za'im[2] | 11 April 1949 | 14 August 1949 | Husni al-Za'im | |
| none | 14 August 1949 | 15 August 1949 | Sami al-Hinnawi | |
| none | 15 August 1949 | 2 December 1951 | Hashim al-Atassi | |
| none | 3 December 1951 | 11 July 1953 | Fawzi Selu | |
| Fatina al-Fanari[3] | 11 July 1953 | 25 February 1954 | Adib Shishakli | |
| none | 28 February 1954 | 6 September 1955 | Hashim al-Atassi | |
| Bahira al-Dalati | 6 September 1955 | 22 February 1958 | Shukri al-Quwatli | |
| Tahia Kazem (as First Lady of the United Arab Republic) | 22 February 1958 | 14 December 1961 | ||
| Şehire al-Kudsi | 14 December 1961 | 8 March 1963 | ||
| none | 9 March 1963 | 27 July 1963 | Lu'ay al-Atassi | |
| Zeinab al-Hafiz | 27 July 1963 | 23 February 1966 | Amin al-Hafiz | |
| Salma al-Hasibi | 25 February 1966 | 18 November 1970 | Nureddin al-Atassi | |
| Anisa Makhlouf | 12 March 1971 | 10 June 2000 | Hafez al-Assad | |
| Asma al-Assad[4] | 13 December 2000 | Present | Bashar al-Assad |