Federico Sesti Explained

Federico Sesti is an Italian-born neuroscientist and academic at the Robert Wood Johnson Medical School of Rutgers University.^{[1] [2] [3]}

Biography

Sesti obtained his Laurea and Ph.D. in physics from the University of Genoa.^{[4] [5]} Following this, he conducted postdoctoral research at the Institut für Biologische Informationsverarbeitung, Forschungszentrum Jülich in Germany under Benjamin Kaupp and at Yale University in the USA under Steve Goldstein.^{[4] [5]} He joined the faculty of the Robert Wood Johnson Medical School in 2001.^[4]

Sesti has been recognized as a Fulbright Scholar and is a member of various scientific societies.^{[4] [6]} Additionally, Sesti serves on the editorial boards of several journals and serves on panels of several international, federal, and private funding agencies.^[4]

Research

His research topics include ion channels, potassium channels, aging, oxidative stress, reactive oxygen species (ROS), Srctyrosine kinases, C. Elegans, and cell signaling.^{[7] [4] [8]}

Sesti's laboratory has conducted research on the non-conducting functions of ion channels, focusing on the molecular mechanisms of neuronal aging in vertebrates and invertebrates.^[4] Specifically, the lab has studied how excess oxidants affect K+ channels and the role this plays in the decline of neuronal function during aging and in neurodegenerative diseases.^[4]

Selected publications

• Vitali et al. "Apoptotic cell death in disease--current understanding of the NCCD 2023" Cell Death & Differentiation. .
• Forzisi et al. "Antagonistic roles of Ras-MAPK and Akt signaling in Integrin-K+ channel Complexes-mediated cellular apoptosis" The FASEB Journal.
• Wei Y. et al. "Oxidation of KCNB1 channels in the human brain and in mouse model of Alzheimer's disease". Cell Death & Differentiation.
• Sesti F. Oxidation of Ion Channels in the Aging Process.
• Sesti F. "Oxidation of K+ channels in aging and neurodegeneration". Aging and Disease. .
• Cotella D. et al. "Toxic role of K+ channel oxidation in mammalian brain". The Journal of Neuroscience, .
• Sesti F. et al. "Oxidation of K+ channels by ROS: a general mechanism of aging and neurodegeneration?". Trends in Cell Biology,
• Cai S. and F. Sesti. "Oxidation of a potassium channel causes progressive sensory function loss during aging". Nature Neuroscience.
• Park K. and F. Sesti (2007). "An arrhythmia susceptibility gene in Caenorhabditis elegans" Journal of Biological Chemistry. .
• Cai S. et al. "MPS-1 is a K+ channel β-subunit and a serine/threonine kinase". Nature Neuroscience.
• Park K., et al. "Single-walled carbon nanotubes: A new class of ion-channel blockers". Journal of Biological Chemistry. Dec 12;278(50):50212-6
• Sesti F. et al. "A common polymorphism associated with cardiac arrhythmia increases sensitivity to a common antibiotic". Proceedings of the National Academy of Sciences of the United States of America,
• Abbot G.W. et al. "MiRP1 forms Ikr potassium channels with HERG and is associated with cardiac arrhythmia". Cell,
• Sesti F. and S.A.N. Goldstein "Single-channel characteristics of wildtype Iks channels and channels formed with two MinK mutants that cause long QT syndrome". The Journal of General Physiology, .

Notes and References

1. Web site: Heartbeats: Rutgers Health unveils new suite for pediatric surgical specialists. Brad. Wadlow. Courier News.
2. Web site: Menendez tours Rutgers lab developing groundbreaking Alzheimer's treatment. Staff Report. Courier News.
3. Web site: Federico Sesti, Rutgers Robert Wood Johnson Medical School. EurekAlert!.
4. Web site: Federico Sesti | Professor Neuroscience and Cell Biology Robert Wood Johnson Medical School Rutgers University.
5. Web site: USIEF. https://web.archive.org/web/20230704190513/https://www.usief.org.in/USF-2014-15/Fulbright-Nehru%20Academic%20and%20Professional%20Excellence%20Awards/Teaching%20and%20Research/Sesti-Federico.html . 2023-07-04 .
6. Web site: Local Rutgers professors receive Fulbright grants. Rutgers. University. Courier News.
7. Web site: Oxidation Alters Ion Channels During Aging. Chemical & Engineering News.
8. Web site: More Than Just Pores.