FREM2 explained

FRAS1-related extracellular matrix protein 2 is a protein that in humans is encoded by the FREM2 gene.^{[1] [2]}

This gene encodes a membrane protein that belongs to the FRAS1 family. This extracellular matrix protein is thought to be required for maintaining the integrity of the skin epithelium and the differentiated state of renal epithelia. The protein localizes to the basement membrane, forming a ternary complex that plays a role in epidermal-dermal interactions during morphogenetic processes. Mutations in this gene are associated with Fraser syndrome.

Further reading

• Timmer JR, Mak TW, Manova K, Anderson KV, Niswander L . Tissue morphogenesis and vascular stability require the Frem2 protein, product of the mouse myelencephalic blebs gene. . Proc. Natl. Acad. Sci. U.S.A. . 102 . 33 . 11746–50 . 2005 . 16087869 . 10.1073/pnas.0505404102 . 1183448 . 2005PNAS..10211746T . etal. free .
• Dias Neto E, Correa RG, Verjovski-Almeida S . Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. . Proc. Natl. Acad. Sci. U.S.A. . 97 . 7 . 3491–6 . 2000 . 10737800 . 10.1073/pnas.97.7.3491. 16267 . 2000PNAS...97.3491D . etal. free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Dunham A, Matthews LH, Burton J . The DNA sequence and analysis of human chromosome 13. . Nature . 428 . 6982 . 522–8 . 2004 . 15057823 . 10.1038/nature02379 . 2665288 . 2004Natur.428..522D . etal.
• Brandenberger R, Wei H, Zhang S . Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. . Nat. Biotechnol. . 22 . 6 . 707–16 . 2005 . 15146197 . 10.1038/nbt971 . 27764390 . etal.
• Jadeja S, Smyth I, Pitera JE . Identification of a new gene mutated in Fraser syndrome and mouse myelencephalic blebs. . Nat. Genet. . 37 . 5 . 520–5 . 2005 . 15838507 . 10.1038/ng1549 . 7666665 . etal.
• Liu T, Qian WJ, Gritsenko MA . Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. . J. Proteome Res. . 4 . 6 . 2070–80 . 2006 . 16335952 . 10.1021/pr0502065 . 1850943 . etal.
• Kiyozumi D, Sugimoto N, Sekiguchi K . Breakdown of the reciprocal stabilization of QBRICK/Frem1, Fras1, and Frem2 at the basement membrane provokes Fraser syndrome-like defects. . Proc. Natl. Acad. Sci. U.S.A. . 103 . 32 . 11981–6 . 2006 . 16880404 . 10.1073/pnas.0601011103 . 1567684 . 2006PNAS..10311981K . free .

Notes and References

1. Smyth I, Du X, Taylor MS, Justice MJ, Beutler B, Jackson IJ . The extracellular matrix gene Frem1 is essential for the normal adhesion of the embryonic epidermis . Proc Natl Acad Sci U S A . 101 . 37 . 13560–5 . Sep 2004 . 15345741 . 518794 . 10.1073/pnas.0402760101 . 2004PNAS..10113560S . free .
2. Web site: Entrez Gene: FREM2 FRAS1 related extracellular matrix protein 2.