FOXN3 explained

Forkhead box protein N3 is a protein that in humans is encoded by the FOXN3 gene.^{[1] [2]}

This gene is a member of the forkhead/winged helix transcription factor family. Checkpoints are eukaryotic DNA damage-inducible cell cycle arrests at G1 and G2. Checkpoint suppressor 1 suppresses multiple yeast checkpoint mutations including mec1, rad9, rad53 and dun1 by activating a MEC1-independent checkpoint pathway. Alternative splicing is observed at the locus, resulting in distinct isoforms.

See also

• FOX proteins

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Field LL, Tobias R, Thomson G, Plon S . Susceptibility to insulin-dependent diabetes mellitus maps to a locus (IDDM11) on human chromosome 14q24.3-q31. . Genomics . 33 . 1 . 1–8 . 1996 . 8617492 . 10.1006/geno.1996.0153 .
• Hillier LD, Lennon G, Becker M . Generation and analysis of 280,000 human expressed sequence tags. . Genome Res. . 6 . 9 . 807–28 . 1997 . 8889549 . 10.1101/gr.6.9.807 . etal. free .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . etal.
• Yu Y, Zhang C, Zhou G . Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs. . Genome Res. . 11 . 8 . 1392–403 . 2001 . 11483580 . 10.1101/gr.175501 . 311073 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Heilig R, Eckenberg R, Petit JL . The DNA sequence and analysis of human chromosome 14. . Nature . 421 . 6923 . 601–7 . 2003 . 12508121 . 10.1038/nature01348 . 2003Natur.421..601H . etal. free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Lehner B, Sanderson CM . A protein interaction framework for human mRNA degradation. . Genome Res. . 14 . 7 . 1315–23 . 2004 . 15231747 . 10.1101/gr.2122004 . 442147 .
• Suzuki Y, Yamashita R, Shirota M . Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. . Genome Res. . 14 . 9 . 1711–8 . 2004 . 15342556 . 10.1101/gr.2435604 . 515316 . etal.
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Scott KL, Plon SE . CHES1/FOXN3 interacts with Ski-interacting protein and acts as a transcriptional repressor. . Gene . 359 . 119–26 . 2005 . 16102918 . 10.1016/j.gene.2005.06.014 .
• Busygina V, Kottemann MC, Scott KL . Multiple endocrine neoplasia type 1 interacts with forkhead transcription factor CHES1 in DNA damage response. . Cancer Res. . 66 . 17 . 8397–403 . 2007 . 16951149 . 10.1158/0008-5472.CAN-06-0061 . etal. free .
• Katoh H, Ojima H, Kokubu A . Genetically distinct and clinically relevant classification of hepatocellular carcinoma: putative therapeutic targets. . Gastroenterology . 133 . 5 . 1475–86 . 2007 . 17983802 . 10.1053/j.gastro.2007.08.038 . etal. free .

Notes and References

1. Pati D, Keller C, Groudine M, Plon SE . Reconstitution of a MEC1-independent checkpoint in yeast by expression of a novel human fork head cDNA . Mol Cell Biol . 17 . 6 . 3037–46 . Jun 1997 . 10.1128/MCB.17.6.3037 . 9154802 . 232156 .
2. Web site: Entrez Gene: CHES1 checkpoint suppressor 1.