FKBP3 explained

FK506-binding protein 3 also known as FKBP25 is a protein that in humans is encoded by the FKBP3 gene.^{[1] [2]}

Function

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin.^{[3] [4]}

Interactions

FKBP3 has been shown to interact with YY1,^[5] HDAC1,^[5] Histone deacetylase 2,^[5] DNA,^[6] and Mdm2.^[7] Both crystal structure of FKBP25 with FK506 and the NMR structure of full length FKBP25 has been published with PDB ID 5D75 and 2MPH respectively.^{[3] [8]}

Further reading

• Jin YJ, Burakoff SJ, Bierer BE . Molecular cloning of a 25-kDa high affinity rapamycin binding protein, FKBP25 . J. Biol. Chem. . 267 . 16 . 10942–5 . 1992 . 10.1016/S0021-9258(19)49856-6 . 1375932 . free .
• Wiederrecht G, Martin MM, Sigal NH, Siekierka JJ . Isolation of a human cDNA encoding a 25 kDa FK-506 and rapamycin binding protein . Biochem. Biophys. Res. Commun. . 185 . 1 . 298–303 . 1992 . 1376117 . 10.1016/S0006-291X(05)80990-8 .
• Jin YJ, Burakoff SJ . The 25-kDa FK506-binding protein is localized in the nucleus and associates with casein kinase II and nucleolin . Proc. Natl. Acad. Sci. U.S.A. . 90 . 16 . 7769–73 . 1993 . 7689229 . 47224 . 10.1073/pnas.90.16.7769 . 1993PNAS...90.7769J . free .
• Cross SH, Charlton JA, Nan X, Bird AP . Purification of CpG islands using a methylated DNA binding column . Nat. Genet. . 6 . 3 . 236–44 . 1994 . 8012384 . 10.1038/ng0394-236 . 12847618 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Meng X, Chen J, Yang Q, Wang S, Chao Y, Ying K, Xie Y, Mao Y . Cloning and identification of a novel cDNA which may be associated with FKBP25 . Biochem. Genet. . 40 . 9–10 . 303–10 . 2002 . 12392168 . 10.1023/A:1020256718720 . 24265377 .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Peptidyl-prolyl cis-trans isomerase FKBP3
• PDBe-KB provides an overview of all the structure information available in the PDB for Mouse Peptidyl-prolyl cis-trans isomerase FKBP3

Notes and References

1. Hung DT, Schreiber SL . cDNA cloning of a human 25 kDa FK506 and rapamycin binding protein . Biochem. Biophys. Res. Commun. . 184 . 2 . 733–8 . Jun 1992 . 1374240 . 10.1016/0006-291X(92)90651-Z .
2. Porat R, Poutsiaka DD, Miller LC, Granowitz EV, Dinarello CA . Interleukin-1 (IL-1) receptor blockade reduces endotoxin and Borrelia burgdorferi-stimulated IL-8 synthesis in human mononuclear cells . FASEB J. . 6 . 7 . 2482–6 . May 1992 . 10.1096/fasebj.6.7.1532945 . free . 1532945 . 29899093 .
3. Prakash . Ajit . Rajan . Sreekanth . Yoon . Ho Sup . April 2016 . Crystal structure of the FK506 binding domain of human FKBP25 in complex with FK506 . Protein Science . 25 . 4 . 905–910 . 10.1002/pro.2875 . 1469-896X . 4941220 . 26749369.
4. Web site: Entrez Gene: FKBP3 FK506 binding protein 3, 25kDa.
5. Yang WM, Yao YL, Seto E . The FK506-binding protein 25 functionally associates with histone deacetylases and with transcription factor YY1 . EMBO J. . 20 . 17 . 4814–25 . Sep 2001 . 11532945 . 125595 . 10.1093/emboj/20.17.4814 .
6. Prakash A, Shin J, Rajan S, Yoon HS . Structural basis of nucleic acid recognition by FK506-binding protein 25 (FKBP25), a nuclear immunophilin . Nucleic Acids Res. . 44 . 6 . 2909–25 . 2016 . 26762975 . 4824100 . 10.1093/nar/gkw001.
7. Ochocka AM, Kampanis P, Nicol S, Allende-Vega N, Cox M, Marcar L, Milne D, Fuller-Pace F, Meek D . FKBP25, a novel regulator of the p53 pathway, induces the degradation of MDM2 and activation of p53 . FEBS Lett. . 583 . 4 . 621–6 . Feb 2009 . 19166840 . 10.1016/j.febslet.2009.01.009 . 6110 .
8. Prakash . Ajit . Shin . Joon . Rajan . Sreekanth . Yoon . Ho Sup . 2016-04-07 . Structural basis of nucleic acid recognition by FK506-binding protein 25 (FKBP25), a nuclear immunophilin . Nucleic Acids Research . 44 . 6 . 2909–2925 . 10.1093/nar/gkw001 . 26762975 . 4824100 . 0305-1048.