FCER1G explained

Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide is gamma chain of high affinity IgE receptor. This protein is encoded by the FCER1G gene in humans.^[1]

Function

The high affinity IgE receptor, FcεRI, is a key molecule involved in allergic reactions. It is a tetramer composed of 1 alpha, 1 beta, and 2 gamma chains. The gamma chains are also subunits of other Fc receptors. [provided by RefSeq, Jul 2008].

Further reading

• Tsuji M, Ezumi Y, Arai M, Takayama H . A novel association of Fc receptor gamma-chain with glycoprotein VI and their co-expression as a collagen receptor in human platelets . The Journal of Biological Chemistry . 272 . 38 . 23528–31 . September 1997 . 9295288 . 10.1074/jbc.272.38.23528 . free .
• Kihara H, Siraganian RP . Src homology 2 domains of Syk and Lyn bind to tyrosine-phosphorylated subunits of the high affinity IgE receptor . The Journal of Biological Chemistry . 269 . 35 . 22427–32 . September 1994 . 10.1016/S0021-9258(17)31807-0 . 8071371 . free .
• Huang L, Chen S, Zha X, Yang L, Li B, Yu Z, Wang L, Li Y . Expression feature of CD3, FcεRIγ, and Zap-70 in patients with chronic lymphocytic leukemia . Hematology . 17 . 2 . 71–5 . March 2012 . 22664044 . 10.1179/102453312X13221316477895 . 24701040 . free .
• Kim YK, Park HW, Yang JS, Oh SY, Chang YS, Shin ES, Lee JE, Kim S, Gho YS, Cho SH, Min KU, Kim YY . Association and functional relevance of E237G, a polymorphism of the high-affinity immunoglobulin E-receptor beta chain gene, to airway hyper-responsiveness . Clinical and Experimental Allergy . 37 . 4 . 592–8 . April 2007 . 17430357 . 10.1111/j.1365-2222.2007.02680.x . 25869901 .
• Zha X, Yan X, Shen Q, Zhang Y, Wu X, Chen S, Li B, Yang L, Geng S, Weng J, Du X, Li Y . Alternative expression of TCRζ related genes in patients with chronic myeloid leukemia . Journal of Hematology & Oncology . 5 . 74 . December 2012 . 23228155 . 3544630 . 10.1186/1756-8722-5-74 . free .
• Takahashi K, Hayashi N, Shimokawa T, Umehara N, Kaminogawa S, Ra C . Cooperative regulation of Fc receptor gamma-chain gene expression by multiple transcription factors, including Sp1, GABP, and Elf-1 . The Journal of Biological Chemistry . 283 . 22 . 15134–41 . May 2008 . 18378679 . 3258888 . 10.1074/jbc.M800498200 . free .
• Bao M, Hanabuchi S, Facchinetti V, Du Q, Bover L, Plumas J, Chaperot L, Cao W, Qin J, Sun SC, Liu YJ . CD2AP/SHIP1 complex positively regulates plasmacytoid dendritic cell receptor signaling by inhibiting the E3 ubiquitin ligase Cbl . Journal of Immunology . 189 . 2 . 786–92 . July 2012 . 22706086 . 3665352 . 10.4049/jimmunol.1200887 .
• Gross BS, Melford SK, Watson SP . Evidence that phospholipase C-gamma2 interacts with SLP-76, Syk, Lyn, LAT and the Fc receptor gamma-chain after stimulation of the collagen receptor glycoprotein VI in human platelets . European Journal of Biochemistry . 263 . 3 . 612–23 . August 1999 . 10469124 . 10.1046/j.1432-1327.1999.00560.x . free .
• Kumar P, Singh B, Lal R, Rembhotkar GW, Singh AB . Association between reduced levels of total serum IgE and FcepsilonRI expression in non-releaser basophils . Immunobiology . 214 . 5 . 377–83 . 2009 . 19362683 . 10.1016/j.imbio.2008.09.008 .

Notes and References

1. Web site: Entrez Gene: Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide .