FBXO9 explained

F-box only protein 9 is a protein that in humans is encoded by the FBXO9 gene.^{[1] [2] [3]}

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates at least 3 transcript variants diverging at the 5' terminus.

Further reading

• Hillier LD, Lennon G, Becker M . Generation and analysis of 280,000 human expressed sequence tags . Genome Res. . 6 . 9 . 807–28 . 1997 . 8889549 . 10.1101/gr.6.9.807 . etal. free .
• Scanlan MJ, Gordan JD, Williamson B . Antigens recognized by autologous antibody in patients with renal-cell carcinoma . Int. J. Cancer . 83 . 4 . 456–64 . 1999 . 10508479 . 10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5 . etal. 21839750 .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Mungall AJ, Palmer SA, Sims SK . The DNA sequence and analysis of human chromosome 6 . Nature . 425 . 6960 . 805–11 . 2003 . 14574404 . 10.1038/nature02055 . 2003Natur.425..805M . etal. free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Jin J, Cardozo T, Lovering RC . Systematic analysis and nomenclature of mammalian F-box proteins . Genes Dev. . 18 . 21 . 2573–80 . 2005 . 15520277 . 10.1101/gad.1255304 . 525538 . etal.

Notes and References

1. Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M . Identification of a family of human F-box proteins . Curr Biol . 9 . 20 . 1177–9 . Dec 1999 . 10531035 . 10.1016/S0960-9822(00)80020-2 . 7467493 . free . 1999CBio....9.1177C .
2. Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW . A family of mammalian F-box proteins . Curr Biol . 9 . 20 . 1180–2 . Dec 1999 . 10531037 . 10.1016/S0960-9822(00)80021-4 . 14341845 . free . 1999CBio....9.1180W .
3. Web site: Entrez Gene: FBXO9 F-box protein 9.