FBXO6 explained

F-box only protein 6 is a protein that in humans is encoded by the FBXO6 gene.^{[1] [2] [3]}

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class, and its C-terminal region is highly similar to that of rat NFB42 (neural F Box 42 kDa) which may be involved in the control of the cell cycle.

Further reading

• Gregory SG, Barlow KF, McLay KE . The DNA sequence and biological annotation of human chromosome 1. . Nature . 441 . 7091 . 315–21 . 2006 . 16710414 . 10.1038/nature04727 . 2006Natur.441..315G . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Yoshida Y, Tokunaga F, Chiba T . Fbs2 is a new member of the E3 ubiquitin ligase family that recognizes sugar chains. . J. Biol. Chem. . 278 . 44 . 43877–84 . 2003 . 12939278 . 10.1074/jbc.M304157200 . etal. free.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Ilyin GP, Sérandour AL, Pigeon C . A new subfamily of structurally related human F-box proteins. . Gene . 296 . 1–2 . 11–20 . 2003 . 12383498 . 10.1016/S0378-1119(02)00867-3 . etal.
• Winston JT, Koepp DM, Zhu C . A family of mammalian F-box proteins. . Curr. Biol. . 9 . 20 . 1180–2 . 1999 . 10531037 . 10.1016/S0960-9822(00)80021-4 . 14341845 . etal. free . 1999CBio....9.1180W .

Notes and References

1. Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M . Identification of a family of human F-box proteins . Curr Biol . 9 . 20 . 1177–9 . Dec 1999 . 10531035 . 10.1016/S0960-9822(00)80020-2 . 7467493 . free . 1999CBio....9.1177C .
2. Ilyin GP, Rialland M, Pigeon C, Guguen-Guillouzo C . cDNA cloning and expression analysis of new members of the mammalian F-box protein family . Genomics . 67 . 1 . 40–7 . Nov 2000 . 10945468 . 10.1006/geno.2000.6211 .
3. Web site: Entrez Gene: FBXO6 F-box protein 6.