FAM114A2 explained

FAM114A2 (chromosome 5 open reading frame 3) is a gene on chromosome 5 in humans that encodes a protein FAM114A2. The protein function is not well known. FAM114A2 is, however, highly conserved in mammals with homologs both in fungi and plants.

Species	Accession #	Identity
macaca mulatta	XM_001102467	78.1%
Pan troglodytes	XM_518045	89.7%
bos taurus	NP_001033166	85.6%
Pongo abelii	XM_002816109	87.8%
Mus musculus	NM_026342.3	79%
Callithrix jacchus	XP_002744467	94.7%

Protein

The FAM114A2 protein is 505 amino acids long^[1] with a molecular weight of 55.5 kdal and an isoelectric point of 4.66.^[2] It is predicted to stay in the nucleus after translation ^[3] There is evidence that c5orf3 interacts with another protein of unknown function from chromosome 5, c5orf4 ^[4] This protein is thought to include a P loop^[5] that suggests a role in ATP- and/or GTP-binding ^[6]

Gene

The FAM114A2 gene is located on chromosome 5 (5q31-33).^[7] This gene has 14 exons spanning through its sequence.^[1] The coding sequence is 2886 base pairs with a 5’ UTR of 94 base pairs and a 3’ UTR of 1273 base pairs.^[1] It is expressed at high levels in most tissues of the human body.^[7] It is also highly expressed in tissues in the human brain ^[8]

Further reading

• Kimura K . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 . vanc. Wakamatsu A . Suzuki Y . 3 . Ota . T . Nishikawa . T . Yamashita . R . Yamamoto . J . Sekine . M . Tsuritani . K .
• Gerhard DS . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Suzuki Y . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . vanc. Yoshitomo-Nakagawa K . Maruyama K . 3 . Suyama . A . Sugano . S .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .

Notes and References

1. https://www.ncbi.nlm.nih.gov/nuccore/NM_018691.2 Homo sapiens family with sequence similarity 114, member A2 (FAM114A2) - Nucleotide - NCBI
2. Biology workbench: http://seqtool.sdsc.edu/CGI/BW.cgi#!
3. http://psort.hgc.jp/ PSORT WWW Server
4. STRING: http://string-db.org/newstring_cgi/show_network_section.pl.
5. Web site: STRING: Functional protein association networks.
6. 2126155 . 15 . 11 . The P-loop--a common motif in ATP- and GTP-binding proteins . November 1990 . Trends Biochem. Sci. . 430–4 . Saraste M, Sibbald PR, Wittinghofer A . 10.1016/0968-0004(90)90281-f.
7. https://www.genecards.org/cgi-bin/carddisp.pl?gene=FAM114A2&search=c5orf3 FAM114A2 Gene - GeneCards | F1142 Protein | F1142 Antibody
8. Allen Brain Atlas: http://human.brain-map.org/search?type=mi