| Ernst Gerhard Wilhelm Keyl | |
| Birth Date: | 22 May 1804 |
| Birth Place: | Leipzig, Germany |
| Death Place: | Monroe, Michigan |
| President, Eastern District of the Lutheran Church–Missouri Synod | |
| Term: | 1854–1869 |
| Education: | Leipzig University, 1829 |
| Occupation: | Pastor |
| Years Active: | 1829–1871 |
Ernst Gerhard Wilhelm Keyl (May 22, 1804 in Leipzig, Germany – August 4, 1872 in Monroe, Michigan) was a German-born Lutheran clergyman who worked in the United States. He was a founder and the first president of the Eastern District of the Lutheran Church–Missouri Synod's (LCMS).
Keyl graduated from Leipzig University in 1829 and served as a pastor Niederfrohna, near Penig, beginning in 1829. As a follower of Martin Stephan, he emigrated to the United States in 1839 in the Saxon Emigration. He later served as pastor in Frohna, Missouri (1839–1847); Freistadt and Milwaukee, Wisconsin (1847–1850); Baltimore, Maryland (1850–1869); and Willshire, Ohio. (1869–1871). He was the first president of the Eastern District of the LCMS from 1854 to 1869). He was a scholar of the life and work of Martin Luther.
His biography was published by J. F. Kostering (St. Louis, 1882).