Eric Block Explained
Eric Block (born January 25, 1942) is an American chemist whose research has focused on the chemistry of organosulfur and organoselenium compounds, Allium chemistry (the chemistry of garlic, onion, and other alliums), and the chemistry of olfaction. As of 2018, he is Distinguished Professor of Chemistry Emeritus at the University at Albany, SUNY.
Biography
Eric Block was born in New York City in 1942. He received his B.S. (1962) degree from Queens College of the City University of New York, where he was elected to Phi Beta Kappa. After a research assistant position at Brookhaven National Laboratories he attended Harvard University, where he received his M.S. (1964), and Ph.D. (1967) degrees as both a National Science Foundation and National Institutes of Health Predoctoral Fellow, working with E. J. Corey as a graduate student in the area of organic synthesis using organosulfur compounds. After a postdoctoral fellowship at Harvard with E. J. Corey, Block joined the faculty at the University of Missouri–St. Louis in 1967, becoming Professor in 1979. In 1981, he moved to the University at Albany, SUNY, where he was Chair of Chemistry from 1985–1991. He was named Distinguished Professor in 2002 and Carla Rizzo Delray Professor in 2006. In 2018 he became Emeritus Professor at Albany and Visiting Professor in the Chemistry Department at University of California, Irvine.
Block has also held visiting positions at the Harvard University (1974), University of Bologna (1984), Weizmann Institute (2000), Wolfson College, University of Cambridge (2006), Chinese Academy of Sciences (2013), and University of California, Los Angeles (2018).
Research areas
Block is known for his research on organosulfur and organoselenium chemistry, particularly that of genus Allium plants, such as garlic and onion. This work is summarized in two monographs, two review articles, and is the subject of a 2014 American Chemical Society Webinar.[1] Block's monograph on alliums[2] has been published in a Chinese edition. Since 2005, another major area of collaborative research with neurobiology and computational chemistry colleagues has been the study of the molecular basis for olfaction, particularly the role of metals such as copper in olfaction and molecular mechanisms for sensing thiols[3] as well as musk, such as muscone. With his collaborators Block has also examined the plausibility of the controversial vibration theory of olfaction, reaching the conclusion that it is implausible.[4] [5]
Service
Since 1994, Block has been an editorial board member of the Journal of Agricultural and Food Chemistry.[6] Block also served as associate editor (1984–1988) and editorial board member (1984–2000), for Phosphorus, Sulfur, Silicon and the Related Elements, as editorial board member and founding member of Heteroatom Chemistry, 1990–1995,[7] and as associate editor for Organic Reactions, Volume 30.[8] Block was a founding member and international advisory board member of the International Conference on Heteroatom Chemistry (ICHAC) series of meetings,[9] and Chair of ICHAC-2, held in Albany, NY in 1989.[10] [11] He was also Chair of the Symposium on New Organosulfur Chemistry, Pacifichem 2015 in Honolulu, HI.
Honors and awards
Selected publications
Block has published five books and 258 articles; his books and several of his most cited and recent papers are listed below.
- Books
- Book: Block, E.. Reactions of Organosulfur Compounds. Academic Press. 1978. 978-0-12-107050-2.
- Book: Block, E.. Heteroatom Chemistry. VCH. 1990. 978-3-527-27858-9.
- Book: Block, E.. Advances in Sulfur Chemistry. JAI Press. 1994. 0-89232-868-1.
- Book: Block, E.. Garlic and Other Alliums: The Lore and the Science. Royal Society of Chemistry. 2010. 978-0-85404-190-9.
- Book: Block, E.. Garlic and Other Alliums: The Lore and the Science, Chinese Edition [神奇的葱蒜—传说与科学] . Chemistry Industry Press. 2017. 978-7-122-28930-8.
- Reviews
- Block, E. . 1985 . The chemistry of garlic and onions. Scientific American . 252 . 3. 114–119 . 3975593. 10.1038/scientificamerican0385-114 . 1985SciAm.252c.114B .
- Block, E. . 50827982 . 1992 . The organosulfur chemistry of the genus Allium — implications for organic sulfur chemistry . Angewandte Chemie International Edition . 104 . 9. 1158–1203 . 10.1002/anie.199211351.
- Block . E. . Batista . V.S. . Matsunami . H. . Zhuang . H. . Ahmed . L.. 2017 . The role of metals in mammalian olfaction of low molecular weight organosulfur compounds. . Natural Product Reports . 34 . 5. 529–557 . 10.1039/c7np00016b . 28471462. 5542778 .
- Block, E. . 2018 . Molecular basis of mammalian odor discrimination: A status report . Journal of Agricultural and Food Chemistry . 66 . 51. 13346–13366 . 10.1021/acs.jafc.8b04471. 30453735. 53873781 .
- Research papers
- Lin . D.Y. . Zhang . S.Z. . Block . E. . Katz . L.C. . 2005 . Encoding social signals in the mouse main olfactory bulb . Nature . 434 . 7032. 470–477 . 10.1038/nature03414 . 15724148. 2005Natur.434..470L . 162036 .
- Duan . X. . Block . E. . Li . Z. . Connelly . T. . Zhang . J. . Huang . Z. . Su . X. . Pan . Y. . Wu . L. . Chi . Q. . Thomas . S. . Zhang . S. . Ma . M. . Matsunami . H. . Chen . G.-Q. . Zhang . H. . Crucial role of copper in detection of metal-coordinating odorants . Proc. Natl. Acad. Sci. USA . 2012 . 109 . 9 . 3492–3497 . 10.1073/pnas.1111297109. 2012PNAS..109.3492D . 22328155 . 3295281. free .
- Block, E. . Implausibility of the vibrational theory of olfaction. Proc. Natl. Acad. Sci. USA . 112. 21. E2766–E2774. 2015. 10.1073/pnas.1503054112. 25901328 . 4450420. etal. 2015PNAS..112E2766B. free.
- Li . S. . Ahmed . L. . Zhang . R. . Pan . Y. . Matsunami . H. . Burger . J. L. . Block . E. . Batista . V. S. . Zhuang . H. . 7865518 . 2016. Smelling sulfur: Copper and silver regulate the response of human odorant receptor OR2T11 to low molecular weight thiols. Journal of the American Chemical Society . 138 . 40 . 13281–13288 . 10.1021/jacs.6b06983 . 27659093.
- Ahmed, L.. Molecular mechanism of activation of human musk receptors OR5AN1 and OR1A1 by (R)-muscone and diverse other musk-smelling compounds. . 115. 17. E3950–E3958. 2018. 10.1073/pnas.1713026115. 29632183. 5924878. 2018PNAS..115E3950A . etal. free.
- Block . E. . Dethier . B. . Bechand . B. . Cotelesage . J.J.H. . George . G.N. . Goto . K. . Pickering . I.J. . Rengifo . E.M. . Sheridan . R. . Sneeden . E.Y. . Vogt . L. . 2018 . Ajothiolanes: 3,4-Dimethylthiolane natural products from garlic (Allium sativum) . Journal of Agricultural and Food Chemistry . 66 . 39. 10193–10204 . 10.1021/acs.jafc.8b03638. 30196701. 1490686 . 52178061 .
- Haag . F. . Ahmed . L. . Reiss . K. . Block . E. . Batista . V. . Krautwurst . D. . 2020 . Copper-mediated thiol potentiation and mutagenesis-guided modeling suggest a highly conserved copper-binding motif in human OR2M3 . Cellular and Molecular Life Sciences . 77 . 11 . 2157–2179 . 10.1007/s00018-019-03279-y. 31435697 . 7256108 .
- Vihani . A. . Hu . X.S. . Gundala . S. . Koyama . S. . Block . E. . Matsunami . H. . 2020 . Semiochemical responsive olfactory sensory neurons are sexually dimorphic and plastic . eLife . 9 . 133840 . 10.7554/eLife.54501 . 33231170 . 7732343 . free .
- Mengers . H.G. . Schier . C. . Zimmermann . M. . Gruhlke . M.C.H. . Block . E. . Blank . L.M. . Slusarenko . A.J.. 2022 . Seeing the smell of garlic: Detection of gas phase volatiles from crushed garlic (Allium sativum), onion (Allium cepa), ramsons (Allium ursinum) and human garlic breath using SESI-Orbitrap MS . Food Chemistry . 397 . e54501 . 10.1016/j.foodchem.2022.133804 . 35932686. 251172694 .
- Block . E.. Cotelesage . J.J.H. . Dikarev . E. . Garosi . B. . George . G.N. . Musah . R.A. . Vogt . L.I. . Wei . Z. . Zhang . Y. . 2024 . Re-examination of the claimed isolation of stable noncyclic 1,2-disulfoxides . Organic Letters . 26. 45 . 9619-9624. 10.1021/acs.orglett.4c02849 . free . 11574841 .
External links
Notes and References
- Web site: Garlic and Other Alliums: The Lore and the Science - American Chemical Society. American Chemical Society. 2018-05-15. 2016-05-14. https://web.archive.org/web/20160514221347/http://www.acs.org/content/acs/en/acs-webinars/culinary-chemistry/alliums-garlic.html. dead.
- News: The Chemical Weapons of Onions and Garlic. The New York Times. 2010-06-08. McGee. Harold.
- Web site: Copper key to our sensitivity to rotten eggs' foul smell. chemistryworld.com. 3 May 2018. live. https://web.archive.org/web/20170510113946/https://www.chemistryworld.com/news/copper-key-to-our-sensitivity-to-rotten-eggs-foul-smell/1017492.article. 10 May 2017.
- Everts, S. . Receptor research reignites a smelly debate. Chem. Eng. News . 93. 18. 29–30. 2015.
- Vosshall, L. B. . Laying a controversial smell theory to rest. Proc. Natl. Acad. Sci. USA . 112. 21. 6525–6526. 2015. 10.1073/pnas.1507103112. 26015552. 4450429. 2015PNAS..112.6525V. free.
- Web site: Editorial Board. pubs.acs.org.
- Masthead. 1 December 1990. Heteroatom Chemistry. 1. 6. fmi. 10.1002/hc.520010601. free.
- Web site: Olefin Synthesis via Deoxygenation of Vicinal Diols - Organic Reactions Wiki. organicreactions.org. 2018-06-03. 2022-10-23. https://web.archive.org/web/20221023125240/http://organicreactions.org/index.php/Olefin_Synthesis_via_Deoxygenation_of_Vicinal_Diols. dead.
- Web site: ICHAC 2017. groups.chem.ubc.ca.
- In memory of the late Professor Shigeru Oae. Atsuyoshi. Ohno. 3 June 2018. Heteroatom Chemistry. 13. 5. 388–389. 10.1002/hc.10071. free.
- Web site: ICHAC. www.unioviedo.es.
- Web site: John Simon Guggenheim Foundation | Eric Block . Gf.org . 2014-06-20 . 2018-06-03.
- Web site: Awards . agfd.sites.acs.org . 2018-06-03 . 2020-07-21 . https://web.archive.org/web/20200721140551/https://agfd.sites.acs.org/AGFD%20Awards.pdf . dead .
- Web site: Spencer Award History. Kansas City Local Section.
- Web site: 2012 Sterling B. Hendricks Memorial Lectureship - AGRO Division. www.agrodiv.org.
- Web site: Block, Eric. 1 August 2016.
- Web site: 2014 ACS Fellows - American Chemical Society. American Chemical Society.
- Web site: Ernest Guenther Award in the Chemistry of Natural Products - American Chemical Society. American Chemical Society.
- Web site: 2018 Christopher S. Foote Lecture - UCLA Chemistry and Biochemistry. www.chemistry.ucla.edu.