Endonuclease/Exonuclease/phosphatase family explained

Endonuclease/Exonuclease/phosphatase family is a structural domain found in the large family of proteins including magnesium dependent endonucleases and many phosphatases involved in intracellular signaling.^[1]

Examples

• AP endonuclease proteins,
• DNase I proteins,
• Synaptojanin, an inositol-1,4,5-trisphosphate phosphatase
  • Sphingomyelinase Nocturnin, an NADPH 2' phosphatase^[2]

Subfamilies

• Inositol polyphosphate related phosphatase

Human proteins containing this domain

2'-PDE

2-PDE; ANGEL1; ANGEL2; APEX1; APEX2; CCRN4L; CNOT6;CNOT6L

DNASE1; DNASE1L1; DNASE1L2; DNASE1L3; INPP5A; INPP5B; INPP5D;INPP5E

INPPL1; KIAA1706; OCRL; PIB5PA; SKIP; SMPD2; SMPD3;SYNJ1

SYNJ2; TTRAP; Nocturnin;

References

• Dlakić M . Functionally unrelated signalling proteins contain a fold similar to Mg²⁺-dependent endonucleases . Trends Biochem. Sci. . 25 . 6 . 272–3 . June 2000 . 10838565 . 10.1016/S0968-0004(00)01582-6.
• Mol CD, Kuo CF, Thayer MM, Cunningham RP, Tainer JA . Structure and function of the multifunctional DNA-repair enzyme exonuclease III . Nature . 374 . 6520 . 381–6 . March 1995 . 7885481 . 10.1038/374381a0. 4335526 .
• Lahm A, Suck D . DNase I-induced DNA conformation. 2 A structure of a DNase I-octamer complex . J. Mol. Biol. . 222 . 3 . 645–67 . December 1991 . 1748997 . 10.1016/0022-2836(91)90502-W.

Notes and References

1. Dlaki M . Functionally unrelated signalling proteins contain a fold similar to Mg2+-dependent endonucleases . Trends Biochem. Sci. . 25 . 6 . 272–273 . 2000 . 10838565 . 10.1016/S0968-0004(00)01582-6.
2. Estrella MA, Du J, Chen L, Rath S, Prangley E, Chitrakar A, Aoki T, Schedl P, Rabinowitz J, Korennykh A . The metabolites NADP+ and NADPH are the targets of the circadian protein Nocturnin (Curled) . . 10 . 1 . 2367 . May 2019 . 31147539 . 10.1038/s41467-019-10125-z . free . 6542800 .
   • May 30, 2019 . Circadian clock and fat metabolism linked through newly discovered mechanism . ScienceDaily .