| Ellen M. Sletten | |
| Workplaces: | University of California, Los Angeles Massachusetts Institute of Technology |
| Alma Mater: | Stonehill College University of California, Berkeley |
| Thesis Title: | Bioorthogonal Chemistries for Labeling Living Systems |
| Thesis Url: | http://www.worldcat.org/oclc/785811176 |
| Thesis Year: | 2011 |
| Doctoral Advisor: | Carolyn R. Bertozzi |
| Known For: | Bioorthogonal Chemistry |
| Website: | Sletten Group |
Ellen Sletten is an American chemist who is the John McTague Career Development Chair at University of California, Los Angeles. Her research considers the use of physical organic chemistry for diagnostics and medical therapies.
Sletten was born in New Hampshire.[1] She earned her bachelor's degree in chemistry at Stonehill College, a liberal arts school in Easton, Massachusetts.[2] Her undergraduate dissertation considered the stereospecific synthesis of pyrrolizidines that could be used as glycosidase inhibitors.[3] She moved to the West Coast of the United States for her graduate studies, joining the laboratory of Carolyn R. Bertozzi at the University of California, Berkeley to work on bioorthogonal chemistry. In particular, Sletten made use of bioorthogonal chemistry for the labelling of living systems, and the synthesis of cyclooctyne reagents in copper-free click chemistry After graduating, Sletten joined the laboratory of Timothy M. Swager at Massachusetts Institute of Technology. At MIT, Sletten worked on fluorescence-based sensors and novel approaches to complex emulsions.[4] [5]
In 2015 Sletten was appointed to the faculty at the University of California, Los Angeles (UCLA). Her research considers the use of physical organic chemistry for diagnostics and medical therapies. In 2017 she realised non-toxic fluorescent compounds that emit in the short-wave infrared region (1000 – 2000 nm), making them appropriate for rapid, in vivo optical diagnostics.[6] At the time, short-wave infrared imaging was widely used in astronomy, but Sletten led its expansion into clinical applications.[7] Short-wave infrared light doesn't scatter much in human tissue, and results in low tissue fluorescence compared to the near-infrared light.[8] By combining the short-wave infrared (flavylium heterocycle-based) fluorophore with lasers and an appropriate camera, Sletten showed it was possible to capture multi-colour images of the veins and arteries of moving mice. As the imaging system could provide real-time feedback, it could be used for image-guided surgery. She has explored the use of nanomaterials containing fluorine for personalised medicine.