| Official Name: | Effingham, South Carolina |
| Settlement Type: | Unincorporated community |
| Pushpin Map: | South Carolina#USA |
| Pushpin Label: | Effingham |
| Subdivision Type: | Country |
| Subdivision Type1: | State |
| Subdivision Type2: | County |
| Subdivision Name: | United States |
| Subdivision Name1: | South Carolina |
| Subdivision Name2: | Florence County |
| Timezone: | Eastern (EST) |
| Utc Offset: | -5 |
| Timezone Dst: | EDT |
| Utc Offset Dst: | -4 |
| Coordinates: | 34.0581°N -79.7531°W |
| Elevation M: | 19 |
| Elevation Ft: | 62 |
| Postal Code Type: | ZIP code |
| Postal Code: | 29541 |
| Area Code: | 843, 854 |
| Blank Name: | GNIS feature ID |
| Blank Info: | 1231263[1] |
Effingham is an unincorporated community in Florence County, South Carolina, United States.[1] Located at the intersection of US 52, US 301 and SC 327, It is a farming community along the northern banks of the Lynches River.
McCall Farms is located in Effingham. Founded in 1838, McCall Farms owns the Margaret Holmes, Glory Foods, Bruce's Yams and Glory Farms canned and frozen foods brands. Their canning facility in Effingham employs 800. In 2006, the company added a frozen foods manufacturing facility.[2]