Ets variant 5 explained

Ets variant 5 (ETV5) (also named ERM transcription factor) is a transcription factor that in humans is encoded by the ETV5 gene.^[1] It is generated in Sertoli cells, which are found in the testes and play a crucial role in spermatogenesis. Its ortholog has been linked to both obesity and bipolar disorder.^[2]

Further reading

• T'sas F, Brenner C, Mauen S, Putmans P, Monté D, Van Lint C, Moser M, Baert JL, de Launoit Y . Expression of the Ets transcription factor Erm is regulated through a conventional PKC signaling pathway in the Molt4 lymphoblastic cell line . FEBS Letters . 579 . 1 . 66–70 . January 2005 . 15620692 . 10.1016/j.febslet.2004.11.052 . 25112599 . free . 2005FEBSL.579...66T .
• Brandys MK, van Elburg AA, Loos RJ, Bauer F, Hendriks J, van der Schouw YT, Adan RA . Are recently identified genetic variants regulating BMI in the general population associated with anorexia nervosa? . American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics . 153B . 2 . 695–9 . March 2010 . 19746409 . 10.1002/ajmg.b.31026 . 45793585 .
• Colas E, Muinelo-Romay L, Alonso-Alconada L, Llaurado M, Monge M, Barbazan J, Gonzalez M, Schoumacher M, Pedrola N, Ertekin T, Devis L, Ruiz A, Castellvi J, Doll A, Gil-Moreno A, Vazquez-Levin M, Lapyckyj L, Lopez-Lopez R, Robine S, Friederich E, Castro M, Reventos J, Vignjevic D, Abal M . ETV5 cooperates with LPP as a sensor of extracellular signals and promotes EMT in endometrial carcinomas . Oncogene . 31 . 45 . 4778–88 . November 2012 . 22266854 . 10.1038/onc.2011.632 . free . 11336/22664 . free .
• Wang X, Yeh S, Wu G, Hsu CL, Wang L, Chiang T, Yang Y, Guo Y, Chang C . Identification and characterization of a novel androgen receptor coregulator ARA267-alpha in prostate cancer cells . The Journal of Biological Chemistry . 276 . 44 . 40417–23 . November 2001 . 11509567 . 10.1074/jbc.M104765200 . free .
• Korz C, Pscherer A, Benner A, Mertens D, Schaffner C, Leupolt E, Döhner H, Stilgenbauer S, Lichter P . Evidence for distinct pathomechanisms in B-cell chronic lymphocytic leukemia and mantle cell lymphoma by quantitative expression analysis of cell cycle and apoptosis-associated genes . Blood . 99 . 12 . 4554–61 . June 2002 . 12036888 . 10.1182/blood.V99.12.4554 . free .
• Chotteau-Lelièvre A, Révillion F, Lhotellier V, Hornez L, Desbiens X, Cabaret V, de Launoit Y, Peyrat JP . Prognostic value of ERM gene expression in human primary breast cancers . Clinical Cancer Research . 10 . 21 . 7297–303 . November 2004 . 15534105 . 10.1158/1078-0432.CCR-04-0593 . 14271353 .
• Planagumà J, Liljeström M, Alameda F, Bützow R, Virtanen I, Reventós J, Hukkanen M . Matrix metalloproteinase-2 and matrix metalloproteinase-9 codistribute with transcription factors RUNX1/AML1 and ETV5/ERM at the invasive front of endometrial and ovarian carcinoma . Human Pathology . 42 . 1 . 57–67 . January 2011 . 20970160 . 10.1016/j.humpath.2010.01.025 .
• Monge M, Colas E, Doll A, Gil-Moreno A, Castellvi J, Diaz B, Gonzalez M, Lopez-Lopez R, Xercavins J, Carreras R, Alameda F, Canals F, Gabrielli F, Reventos J, Abal M . Proteomic approach to ETV5 during endometrial carcinoma invasion reveals a link to oxidative stress . Carcinogenesis . 30 . 8 . 1288–97 . August 2009 . 19443906 . 10.1093/carcin/bgp119 . free .
• Ng MC, Tam CH, So WY, Ho JS, Chan AW, Lee HM, Wang Y, Lam VK, Chan JC, Ma RC . Implication of genetic variants near NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, and KCTD15 with obesity and type 2 diabetes in 7705 Chinese . The Journal of Clinical Endocrinology and Metabolism . 95 . 5 . 2418–25 . May 2010 . 20215397 . 10.1210/jc.2009-2077 . free .

Notes and References

1. Web site: Entrez Gene: Ets variant 5 .
2. Williams MJ, Klockars A, Eriksson A, Voisin S, Dnyansagar R, Wiemerslage L, Kasagiannis A, Akram M, Kheder S, Ambrosi V, Hallqvist E, Fredriksson R, Schiöth HB . The Drosophila ETV5 Homologue Ets96B: Molecular Link between Obesity and Bipolar Disorder . PLOS Genetics . 12 . 6 . e1006104 . June 2016 . 27280443 . 10.1371/journal.pgen.1006104 . 4900636 . free .