EPH receptor A5 explained

EPH receptor A5 (ephrin type-A receptor 5) is a protein that in humans is encoded by the EPHA5 gene.^{[1] [2] [3]}

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.^[4]

Further reading

• Zhou R . Regulation of topographic projection by the Eph family receptor Bsk (EphA5) and its ligands. . Cell Tissue Res. . 290 . 2 . 251–9 . 1997 . 9321686 . 10.1007/s004410050929 . 1506266 .
• Caras IW . A link between axon guidance and axon fasciculation suggested by studies of the tyrosine kinase receptor EphA5/REK7 and its ligand ephrin-A5/AL-1. . Cell Tissue Res. . 290 . 2 . 261–4 . 1997 . 9321687 . 10.1007/s004410050930 . 39695853 .
• Flanagan JG, Vanderhaeghen P . The ephrins and Eph receptors in neural development. . Annu. Rev. Neurosci. . 21 . 309–45 . 1998 . 9530499 . 10.1146/annurev.neuro.21.1.309 .
• Zhou R . The Eph family receptors and ligands. . Pharmacol. Ther. . 77 . 3 . 151–81 . 1998 . 9576626 . 10.1016/S0163-7258(97)00112-5 .
• Holder N, Klein R . Eph receptors and ephrins: effectors of morphogenesis. . Development . 126 . 10 . 2033–44 . 1999 . 10.1242/dev.126.10.2033 . 10207129 .
• Wilkinson DG . Eph receptors and ephrins: regulators of guidance and assembly. . Int. Rev. Cytol. . International Review of Cytology . 196 . 177–244 . 2000 . 10730216 . 10.1016/S0074-7696(00)96005-4 . 9780123646002 .
• Xu Q, Mellitzer G, Wilkinson DG . Roles of Eph receptors and ephrins in segmental patterning. . Philos. Trans. R. Soc. Lond. B Biol. Sci. . 355 . 1399 . 993–1002 . 2001 . 11128993 . 1692797 . 10.1098/rstb.2000.0635 .
• Wilkinson DG . Multiple roles of EPH receptors and ephrins in neural development. . Nat. Rev. Neurosci. . 2 . 3 . 155–64 . 2001 . 11256076 . 10.1038/35058515 . 205014301 .
• Fox GM, Holst PL, Chute HT . cDNA cloning and tissue distribution of five human EPH-like receptor protein-tyrosine kinases. . Oncogene . 10 . 5 . 897–905 . 1995 . 7898931 . etal.
• Davis S, Gale NW, Aldrich TH . Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity. . Science . 266 . 5186 . 816–9 . 1994 . 7973638 . 10.1126/science.7973638 . 1994Sci...266..816D . etal.
• Gale NW, Holland SJ, Valenzuela DM . Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis. . Neuron . 17 . 1 . 9–19 . 1996 . 8755474 . 10.1016/S0896-6273(00)80276-7 . 1075856 . etal. free .
• Miescher GC, Taylor V, Olivieri G . Extensive splice variation and localization of the EHK-1 receptor tyrosine kinase in adult human brain and glial tumors. . Brain Res. Mol. Brain Res. . 46 . 1–2 . 17–24 . 1997 . 9191074 . 10.1016/S0169-328X(96)00268-9 . etal.
• Stein E, Savaskan NE, Ninnemann O . A role for the Eph ligand ephrin-A3 in entorhino-hippocampal axon targeting. . J. Neurosci. . 19 . 20 . 8885–93 . 1999 . 10516308 . 10.1523/JNEUROSCI.19-20-08885.1999. 6782767 . etal. free .

Notes and References

1. Ephnomenclaturecommittee. Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee . Cell . 90 . 3 . 403–4 . Sep 1997 . 9267020 . 10.1016/S0092-8674(00)80500-0. 26773768 . free .
2. Spritz RA, Strunk KM, Lee ST, Lu-Kuo JM, Ward DC, Le Paslier D, Altherr MR, Dorman TE, Moir DT . A YAC contig spanning a cluster of human type III receptor protein tyrosine kinase genes (PDGFRA-KIT-KDR) in chromosome segment 4q12 . Genomics . 22 . 2 . 431–6 . Jan 1995 . 7528718 . 10.1006/geno.1994.1405 . free .
3. Web site: Entrez Gene: EPHA5 EPH receptor A5.
4. Web site: Entrez Gene: EPHA5 EPH receptor A5.