ENAH (gene) explained

Protein enabled homolog is a protein that in humans is encoded by the ENAH gene.^{[1] [2]}

Interactions

ENAH has been shown to interact with ABI1, ZYX,^{[3] [4]} and PCARE.^[5]

Further reading

• Niebuhr K, Ebel F, Frank R, Reinhard M, Domann E, Carl UD, Walter U, Gertler FB, Wehland J, Chakraborty T . 6 . A novel proline-rich motif present in ActA of Listeria monocytogenes and cytoskeletal proteins is the ligand for the EVH1 domain, a protein module present in the Ena/VASP family . The EMBO Journal . 16 . 17 . 5433–5444 . September 1997 . 9312002 . 1170174 . 10.1093/emboj/16.17.5433 .
• Ermekova KS, Zambrano N, Linn H, Minopoli G, Gertler F, Russo T, Sudol M . The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled . The Journal of Biological Chemistry . 272 . 52 . 32869–32877 . December 1997 . 9407065 . 10.1074/jbc.272.52.32869 . free .
• Mammoto A, Sasaki T, Asakura T, Hotta I, Imamura H, Takahashi K, Matsuura Y, Shirao T, Takai Y . 6 . Interactions of drebrin and gephyrin with profilin . Biochemical and Biophysical Research Communications . 243 . 1 . 86–89 . February 1998 . 9473484 . 10.1006/bbrc.1997.8068 .
• Geese M, Schlüter K, Rothkegel M, Jockusch BM, Wehland J, Sechi AS . Accumulation of profilin II at the surface of Listeria is concomitant with the onset of motility and correlates with bacterial speed . Journal of Cell Science . 113 (Pt 8) . 8 . 1415–1426 . April 2000 . 10.1242/jcs.113.8.1415 . 10725224 .
• Krause M, Sechi AS, Konradt M, Monner D, Gertler FB, Wehland J . Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton . The Journal of Cell Biology . 149 . 1 . 181–194 . April 2000 . 10747096 . 2175102 . 10.1083/jcb.149.1.181 .
• Drees B, Friederich E, Fradelizi J, Louvard D, Beckerle MC, Golsteyn RM . Characterization of the interaction between zyxin and members of the Ena/vasodilator-stimulated phosphoprotein family of proteins . The Journal of Biological Chemistry . 275 . 29 . 22503–22511 . July 2000 . 10801818 . 10.1074/jbc.M001698200 . free .
• Krugmann S, Jordens I, Gevaert K, Driessens M, Vandekerckhove J, Hall A . Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex . Current Biology . 11 . 21 . 1645–1655 . October 2001 . 11696321 . 10.1016/S0960-9822(01)00506-1 . 11290377 . free . 2001CBio...11.1645K .
• Coutts AS, MacKenzie E, Griffith E, Black DM . TES is a novel focal adhesion protein with a role in cell spreading . Journal of Cell Science . 116 . Pt 5 . 897–906 . March 2003 . 12571287 . 10.1242/jcs.00278 . 26602119 .
• Tani K, Sato S, Sukezane T, Kojima H, Hirose H, Hanafusa H, Shishido T . Abl interactor 1 promotes tyrosine 296 phosphorylation of mammalian enabled (Mena) by c-Abl kinase . The Journal of Biological Chemistry . 278 . 24 . 21685–21692 . June 2003 . 12672821 . 10.1074/jbc.M301447200 . free .
• Garvalov BK, Higgins TE, Sutherland JD, Zettl M, Scaplehorn N, Köcher T, Piddini E, Griffiths G, Way M . 6 . The conformational state of Tes regulates its zyxin-dependent recruitment to focal adhesions . The Journal of Cell Biology . 161 . 1 . 33–39 . April 2003 . 12695497 . 2172870 . 10.1083/jcb.200211015 .
• Park KW, Morrison CM, Sorensen LK, Jones CA, Rao Y, Chien CB, Wu JY, Urness LD, Li DY . 6 . Robo4 is a vascular-specific receptor that inhibits endothelial migration . Developmental Biology . 261 . 1 . 251–267 . September 2003 . 12941633 . 10.1016/S0012-1606(03)00258-6 . free .
• Giesemann T, Schwarz G, Nawrotzki R, Berhörster K, Rothkegel M, Schlüter K, Schrader N, Schindelin H, Mendel RR, Kirsch J, Jockusch BM . 6 . Complex formation between the postsynaptic scaffolding protein gephyrin, profilin, and Mena: a possible link to the microfilament system . The Journal of Neuroscience . 23 . 23 . 8330–8339 . September 2003 . 12967995 . 6740687 . 10.1523/JNEUROSCI.23-23-08330.2003 .
• Salazar MA, Kwiatkowski AV, Pellegrini L, Cestra G, Butler MH, Rossman KL, Serna DM, Sondek J, Gertler FB, De Camilli P . 6 . Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl homology domains, links dynamin to regulation of the actin cytoskeleton . The Journal of Biological Chemistry . 278 . 49 . 49031–49043 . December 2003 . 14506234 . 10.1074/jbc.M308104200 . free .
• Stüven T, Hartmann E, Görlich D . Exportin 6: a novel nuclear export receptor that is specific for profilin.actin complexes . The EMBO Journal . 22 . 21 . 5928–5940 . November 2003 . 14592989 . 275422 . 10.1093/emboj/cdg565 .
• Di Modugno F, Bronzi G, Scanlan MJ, Del Bello D, Cascioli S, Venturo I, Botti C, Nicotra MR, Mottolese M, Natali PG, Santoni A, Jager E, Nisticò P . 6 . Human Mena protein, a serex-defined antigen overexpressed in breast cancer eliciting both humoral and CD8+ T-cell immune response . International Journal of Cancer . 109 . 6 . 909–918 . May 2004 . 15027125 . 10.1002/ijc.20094 . free .
• Tanoue T, Takeichi M . Mammalian Fat1 cadherin regulates actin dynamics and cell-cell contact . The Journal of Cell Biology . 165 . 4 . 517–528 . May 2004 . 15148305 . 2172355 . 10.1083/jcb.200403006 .
• Krause M, Leslie JD, Stewart M, Lafuente EM, Valderrama F, Jagannathan R, Strasser GA, Rubinson DA, Liu H, Way M, Yaffe MB, Boussiotis VA, Gertler FB . 6 . Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics . Developmental Cell . 7 . 4 . 571–583 . October 2004 . 15469845 . 10.1016/j.devcel.2004.07.024 . free .

Notes and References

1. Sazuka T, Tomooka Y, Kathju S, Ikawa Y, Noda M, Kumar S . Identification of a developmentally regulated gene in the mouse central nervous system which encodes a novel proline rich protein . Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression . 1132 . 3 . 240–248 . October 1992 . 1420303 . 10.1016/0167-4781(92)90156-t . free . 2027.42/29785 .
2. Web site: Entrez Gene: ENAH enabled homolog (Drosophila).
3. Tani K, Sato S, Sukezane T, Kojima H, Hirose H, Hanafusa H, Shishido T . Abl interactor 1 promotes tyrosine 296 phosphorylation of mammalian enabled (Mena) by c-Abl kinase . The Journal of Biological Chemistry . 278 . 24 . 21685–21692 . June 2003 . 12672821 . 10.1074/jbc.M301447200 . free .
4. Drees B, Friederich E, Fradelizi J, Louvard D, Beckerle MC, Golsteyn RM . Characterization of the interaction between zyxin and members of the Ena/vasodilator-stimulated phosphoprotein family of proteins . The Journal of Biological Chemistry . 275 . 29 . 22503–22511 . July 2000 . 10801818 . 10.1074/jbc.M001698200 . free .
5. Hwang T, Parker SS, Hill SM, Ilunga MW, Grant RA, Mouneimne G, Keating AE . A distributed residue network permits conformational binding specificity in a conserved family of actin remodelers . eLife . 10 . e70601 . December 2021 . 34854809 . 10.7554/eLife.70601 . 8639148 . free .