EMG1 explained

Probable ribosome biogenesis protein NEP1 or EMG1 is a protein that in humans is encoded by the EMG1 gene.^{[1] [2] [3]} A D86G mutation in the protein has been associated with Bowen-Conradi syndrome.

Further reading

• Adams MD . Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence . Nature . 377 . 6547 Suppl . 3–174 . 1995 . 7566098 . Kerlavage AR . Fleischmann RD . Fuldner . RA . Bult . CJ . Lee . NH . Kirkness . EF . Weinstock . KG . Gocayne . JD .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Andersen JS . Directed proteomic analysis of the human nucleolus . Curr. Biol. . 12 . 1 . 1–11 . 2002 . 11790298 . 10.1016/S0960-9822(01)00650-9 . Lyon CE . Fox AH . Leung . Anthony K.L. . Lam . Yun Wah . Steen . Hanno . Mann . Matthias . Lamond . Angus I. . 14132033 . free . 2002CBio...12....1A .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . Feingold EA . Grouse LH . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . Wagner L . Feingold EA . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Bernstein KA . The Small-Subunit Processome Is a Ribosome Assembly Intermediate . Eukaryotic Cell . 3 . 6 . 1619–26 . 2005 . 15590835 . 10.1128/EC.3.6.1619-1626.2004 . 539036 . Gallagher JE . Mitchell BM . Granneman . S. . Baserga . S. J. .
• Kimura K . Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 . Wakamatsu A . Suzuki Y . Ota . T . Nishikawa . T . Yamashita . R . Yamamoto . J . Sekine . M . Tsuritani . K .

Notes and References

1. Ansari-Lari MA, Shen Y, Muzny DM, Lee W, Gibbs RA . Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination . Genome Res . 7 . 3 . 268–80 . May 1997 . 9074930 . 10.1101/gr.7.3.268 . free .
2. Eschrich D, Buchhaupt M, Kotter P, Entian KD . Nep1p (Emg1p), a novel protein conserved in eukaryotes and archaea, is involved in ribosome biogenesis . Curr Genet . 40 . 5 . 326–38 . Apr 2002 . 11935223 . 10.1007/s00294-001-0269-4 . 6423295 .
3. Web site: Entrez Gene: EMG1 EMG1 nucleolar protein homolog (S. cerevisiae).