EIF4EBP2 explained

Eukaryotic translation initiation factor 4E-binding protein 2 is a protein that in humans is encoded by the EIF4EBP2 gene.^{[1] [2] [3]}

Animal studies

EIF4EBP2 knockout mice have been used as an animal model of autism. Mice without the Eif4ebp2 gene exhibited autism-like symptoms, including poor social interaction, altered communication and repetitive behaviors. Knockout mice have high levels of Neuroligins.^[4]

Interactions

EIF4EBP2 has been shown to interact with EIF4E.^[5]

Further reading

• Lin TA, Lawrence JC . Control of the translational regulators PHAS-I and PHAS-II by insulin and cAMP in 3T3-L1 adipocytes . The Journal of Biological Chemistry . 271 . 47 . 30199–204 . November 1996 . 8939971 . 10.1074/jbc.271.47.30199 . free .
• Dilling MB, Germain GS, Dudkin L, Jayaraman AL, Zhang X, Harwood FC, Houghton PJ . 4E-binding proteins, the suppressors of eukaryotic initiation factor 4E, are down-regulated in cells with acquired or intrinsic resistance to rapamycin . The Journal of Biological Chemistry . 277 . 16 . 13907–17 . April 2002 . 11847216 . 10.1074/jbc.M110782200 . free .
• Shenberger JS, Adams MH, Zimmer SG . Oxidant-induced hypertrophy of A549 cells is accompanied by alterations in eukaryotic translation initiation factor 4E and 4E-binding protein-1 . American Journal of Respiratory Cell and Molecular Biology . 27 . 2 . 250–6 . August 2002 . 12151318 . 10.1165/ajrcmb.27.2.4785 .
• Ferguson G, Mothe-Satney I, Lawrence JC . Ser-64 and Ser-111 in PHAS-I are dispensable for insulin-stimulated dissociation from eIF4E . The Journal of Biological Chemistry . 278 . 48 . 47459–65 . November 2003 . 14507920 . 10.1074/jbc.M307949200 . free .
• Joshi B, Cameron A, Jagus R . Characterization of mammalian eIF4E-family members . European Journal of Biochemistry . 271 . 11 . 2189–203 . June 2004 . 15153109 . 10.1111/j.1432-1033.2004.04149.x . free .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . October 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 . Huda Zoghbi .

Notes and References

1. Pause A, Belsham GJ, Gingras AC, Donzé O, Lin TA, Lawrence JC, Sonenberg N . Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function . Nature . 371 . 6500 . 762–7 . October 1994 . 7935836 . 10.1038/371762a0 . 1994Natur.371..762P . 4360955 .
2. Tsukiyama-Kohara K, Vidal SM, Gingras AC, Glover TW, Hanash SM, Heng H, Sonenberg N . Tissue distribution, genomic structure, and chromosome mapping of mouse and human eukaryotic initiation factor 4E-binding proteins 1 and 2 . Genomics . 38 . 3 . 353–63 . December 1996 . 8975712 . 10.1006/geno.1996.0638 .
3. Web site: Entrez Gene: EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2.
4. Gkogkas CG, Khoutorsky A, Ran I, Rampakakis E, Nevarko T, Weatherill DB, Vasuta C, Yee S, Truitt M, Dallaire P, Major F, Lasko P, Ruggero D, Nader K, Lacaille JC, Sonenberg N . Autism-related deficits via dysregulated eIF4E-dependent translational control . Nature . 493 . 7432 . 371–7 . January 2013 . 23172145 . 4133997 . 10.1038/nature11628. 2013Natur.493..371G .
5. Mader S, Lee H, Pause A, Sonenberg N . The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4 gamma and the translational repressors 4E-binding proteins . Molecular and Cellular Biology . 15 . 9 . 4990–7 . September 1995 . 7651417 . 230746 . 10.1128/mcb.15.9.4990 .