EIF3K explained

Eukaryotic translation initiation factor 3 subunit K (eIF3k) is a protein that in humans is encoded by the EIF3K gene.^{[1] [2] [3]}

Function

The ~800 kDa eukaryotic initiation factor 3 (eIF3) is the largest eIF and contains at least 12 subunits, including eIF3k/EIF2S12. eIF3 plays an essential role in translation by binding directly to the 40S ribosomal subunit and promoting formation of the 43S preinitiation complex.^[4]

Interactions

eIF3k has been shown to interact with Cyclin D3^[5] and eIF3a.^[6]

See also

• Eukaryotic initiation factor 3 (eIF3)

Further reading

• Karki S, Ligon LA, DeSantis J, Tokito M, Holzbaur EL . PLAC-24 is a cytoplasmic dynein-binding protein that is recruited to sites of cell-cell contact . Molecular Biology of the Cell . 13 . 5 . 1722–34 . May 2002 . 12006665 . 111139 . 10.1091/mbc.02-02-0011 .
• Wei Z, Zhang P, Zhou Z, Cheng Z, Wan M, Gong W . Crystal structure of human eIF3k, the first structure of eIF3 subunits . The Journal of Biological Chemistry . 279 . 33 . 34983–90 . August 2004 . 15180986 . 10.1074/jbc.M405158200 . free .
• Shen X, Yang Y, Liu W, Sun M, Jiang J, Zong H, Gu J . Identification of the p28 subunit of eukaryotic initiation factor 3(eIF3k) as a new interaction partner of cyclin D3 . FEBS Letters . 573 . 1–3 . 139–46 . August 2004 . 15327989 . 10.1016/j.febslet.2004.07.071 . 16005938 . free .
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . November 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .

Notes and References

1. Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z . 6 . Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells . Genome Research . 10 . 10 . 1546–60 . October 2000 . 11042152 . 310934 . 10.1101/gr.140200 .
2. Mayeur GL, Fraser CS, Peiretti F, Block KL, Hershey JW . Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3 . European Journal of Biochemistry . 270 . 20 . 4133–9 . October 2003 . 14519125 . 10.1046/j.1432-1033.2003.03807.x . free .
3. Web site: Entrez Gene: EIF3S12 eukaryotic translation initiation factor 3, subunit 12.
4. Mayeur GL, Fraser CS, Peiretti F, Block KL, Hershey JW . Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3 . European Journal of Biochemistry . 270 . 20 . 4133–9 . 2003 . 14519125 . 10.1046/j.1432-1033.2003.03807.x . free .
5. Shen X, Yang Y, Liu W, Sun M, Jiang J, Zong H, Gu J . Identification of the p28 subunit of eukaryotic initiation factor 3 (eIF3k) as a new interaction partner of cyclin D3 . FEBS Letters . 573 . 1–3 . 139–46 . August 2004 . 15327989 . 10.1016/j.febslet.2004.07.071 . 16005938 . free .
6. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . 6 . Large-scale mapping of human protein-protein interactions by mass spectrometry . Molecular Systems Biology . 3 . 1 . 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .