EIF3I explained

Eukaryotic translation initiation factor 3 subunit I (eIF3i) is a protein that in humans is encoded by the EIF3I gene.^{[1] [2] [3]}

Interactions

eIF3i has been shown to interact with TGF beta 1^[4] and eIF3a.^{[5] [6]}

See also

• Eukaryotic initiation factor 3 (eIF3)

Further reading

• Akoulitchev S, Mäkelä TP, Weinberg RA, Reinberg D . Requirement for TFIIH kinase activity in transcription by RNA polymerase II . Nature . 377 . 6549 . 557–60 . 1995 . 7566158 . 10.1038/377557a0 . 1995Natur.377..557A . 10970696 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Méthot N, Rom E, Olsen H, Sonenberg N . The human homologue of the yeast Prt1 protein is an integral part of the eukaryotic initiation factor 3 complex and interacts with p170 . J. Biol. Chem. . 272 . 2 . 1110–6 . 1997 . 8995410 . 10.1074/jbc.272.2.1110 . free .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Galli-Stauber C, Raho G, Rossi D, Corona DF, Pirola B, Bonaglia MC, Zuffardi O, Sorrentino V . Genomic structure and chromosomal location of the human TGFbeta-receptor interacting protein-1 (TRIP-1) gene to 1p34.1 . FEBS Lett. . 426 . 2 . 279–82 . 1998 . 9599024 . 10.1016/S0014-5793(98)00361-5 . free .
• Choy L, Derynck R . The type II transforming growth factor (TGF)-beta receptor-interacting protein TRIP-1 acts as a modulator of the TGF-beta response . J. Biol. Chem. . 273 . 47 . 31455–62 . 1998 . 9813058 . 10.1074/jbc.273.47.31455 . free .
• Block KL, Vornlocher HP, Hershey JW . Characterization of cDNAs encoding the p44 and p35 subunits of human translation initiation factor eIF3 . J. Biol. Chem. . 273 . 48 . 31901–8 . 1998 . 9822659 . 10.1074/jbc.273.48.31901 . free .
• Poelzl G, Kasai Y, Mochizuki N, Shaul PW, Brown M, Mendelsohn ME . Specific association of estrogen receptor beta with the cell cycle spindle assembly checkpoint protein, MAD2 . Proc. Natl. Acad. Sci. U.S.A. . 97 . 6 . 2836–9 . 2000 . 10706629 . 16016 . 10.1073/pnas.050580997 . 2000PNAS...97.2836P . free .
• McGonigle S, Beall MJ, Pearce EJ . Eukaryotic initiation factor 2 alpha subunit associates with TGF beta receptors and 14-3-3 epsilon and acts as a modulator of the TGF beta response . Biochemistry . 41 . 2 . 579–87 . 2002 . 11781097 . 10.1021/bi011407z .
• Mayeur GL, Fraser CS, Peiretti F, Block KL, Hershey JW . Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3 . Eur. J. Biochem. . 270 . 20 . 4133–9 . 2003 . 14519125 . 10.1046/j.1432-1033.2003.03807.x . free .
• Fraser CS, Lee JY, Mayeur GL, Bushell M, Doudna JA, Hershey JW . The j-subunit of human translation initiation factor eIF3 is required for the stable binding of eIF3 and its subcomplexes to 40 S ribosomal subunits in vitro . J. Biol. Chem. . 279 . 10 . 8946–56 . 2004 . 14688252 . 10.1074/jbc.M312745200 . free .
• Lehner B, Sanderson CM . A protein interaction framework for human mRNA degradation . Genome Res. . 14 . 7 . 1315–23 . 2004 . 15231747 . 442147 . 10.1101/gr.2122004 .
• Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ . Immunoaffinity profiling of tyrosine phosphorylation in cancer cells . Nat. Biotechnol. . 23 . 1 . 94–101 . 2005 . 15592455 . 10.1038/nbt1046 . 7200157 .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Guo D, Han J, Adam BL, Colburn NH, Wang MH, Dong Z, Eizirik DL, She JX, Wang CY . Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress . Biochem. Biophys. Res. Commun. . 337 . 4 . 1308–18 . 2005 . 16236267 . 10.1016/j.bbrc.2005.09.191 .
• Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS . Transcriptome analysis of human gastric cancer . Mamm. Genome . 16 . 12 . 942–54 . 2005 . 16341674 . 10.1007/s00335-005-0075-2 . 69278 .

Notes and References

1. Chen RH, Miettinen PJ, Maruoka EM, Choy L, Derynck R . A WD-domain protein that is associated with and phosphorylated by the type II TGF-beta receptor . Nature . 377 . 6549 . 548–52 . Nov 1995 . 7566156 . 10.1038/377548a0 . 1995Natur.377..548C . 4341262 .
2. Asano K, Kinzy TG, Merrick WC, Hershey JW . Conservation and diversity of eukaryotic translation initiation factor eIF3 . J. Biol. Chem. . 272 . 2 . 1101–9 . Feb 1997 . 8995409 . 10.1074/jbc.272.2.1101 . free .
3. Web site: Entrez Gene: EIF3S2 eukaryotic translation initiation factor 3, subunit 2 beta, 36kDa.
4. Choy L, Derynck R . The type II transforming growth factor (TGF)-beta receptor-interacting protein TRIP-1 acts as a modulator of the TGF-beta response . J. Biol. Chem. . 273 . 47 . 31455–62 . Nov 1998 . 9813058 . 10.1074/jbc.273.47.31455 . free .
5. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . Large-scale mapping of human protein-protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1 . 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .
6. Mayeur GL, Fraser CS, Peiretti F, Block KL, Hershey JW . Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3 . Eur. J. Biochem. . 270 . 20 . 4133–9 . Oct 2003 . 14519125 . 10.1046/j.1432-1033.2003.03807.x . free .